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BACKGROUND The management of minimal, mild and moderate head injuries is still controversial. In 2000, the Scandinavian Neurotrauma Committee (SNC) presented evidence-based guidelines for initial management of these injuries. Since then, considerable new evidence has emerged. METHODS General methodology according to the Appraisal of Guidelines for Research and Evaluation (AGREE) II framework ...

Injuries are a public health crisis. Neurotrauma, specific type of injury, is leading cause death and disability globally, with the largest burden in low- middle-income countries (LMICs). However, there lack quality neurotrauma-specific data LMICs, especially at national level. Without standard criteria for what constitutes registry, significant challenges frequently preventing this level colle...

Chronic neurodegeneration following a history of neurotrauma is frequently associated with neuropsychiatric and cognitive symptoms. In order to enhance understanding about the underlying pathophysiology linking neurotrauma to neurodegeneration, a multi-model preclinical approach must be established to account for the different injury paradigms and pathophysiologic mechanisms. We investigated th...

Blast-induced traumatic brain injury (bTBI) is a signature wound of modern warfare. The current incomplete understanding of its injury mechanism impedes the development of strategies for effective protection of bTBI. Despite a considerable amount of experimental animal studies focused on the evaluation of brain neurotrauma caused by blast exposure, there is very limited knowledge on the biomech...

Objective Among pediatric injury, brain injury is a leading cause of death and disability. To improve outcomes, many developed countries built neurotrauma databank (NTDB) system but there was not established nationwide coverage NTDB until 2009 and there have been few studies on pediatric traumatic head injury (THI) patients in Korea. Therefore, we analyzed epidemiology and outcome from the big ...

BACKGROUND Rehabilitation interventions are a key component of the services required by individuals with neurotrauma to recover or compensate for altered abilities and achieve optimal social participation. Primary studies have produced evidence of the effect of rehabilitation length of stay on individuals with neurotrauma. However, to date no systematic review of this evidence has been performe...

s and Conference Presentations: Hartings JA, Okonkwo DO, Bullock MR, Shutter LA, Mathern B, Strong AJ. Spreading depolarizations and outcome after traumatic brain injury: a prospective observational study. Military Health System Research Symposium (8 Aug 2012; Ft. Lauderdale, FL). Hartings JA, Bullock MR, Zacko C, Vidgeon S, Ridder T, Stanger R, Fabricius M, Mathern B, Tolias C, Pahl C, Strong ...

The past decade has witnessed a resurgence of interest in the use of hypertonic saline for low-volume resuscitation after trauma. Preliminary studies suggested that benefits are limited to a subgroup of trauma patients with brain injury, but a recent study of prehospital administration of hypertonic saline to patients with traumatic brain injury failed to confirm a benefit. Animal and human stu...