Data growth in recent years has been swift, leading to the emergence of big data science. Distributed File Systems (DFS) are commonly used handle data, like Google System (GFS), Hadoop (HDFS), and others. The DFS should provide availability reliability system case failure. replicates files different locations reliability. These replications consume storage space other resources. importance thes...

Although dermal fibroblasts are one of the first cell types exposed to West Nile virus (WNV) during a blood meal by an infected mosquito, little is known about WNV replication within this cell type. Here, we demonstrate that neuroinvasive, WNV-New York (WNV-NY), and nonneuroinvasive, WNV-Australia (WNV-AUS60) strains are able to infect and replicate in primary human dermal fibroblasts (HDFs). H...

2. Introduction Hadoop [1] is an open-source software framework implemented using Java and is designed to be used on large distributed systems. Hadoop is a project of the Apache Software Foundation and is a very popular software tool due, in part, to it being opensource. Yahoo! Has contributed to about 80% of the main core of Hadoop [3], but many other large technology organizations have used o...

In data intensive computing, Hadoop is widely used by organizations. The client applications of Hadoop require high availability and scalability of the system. Mostly, these applications are online and their data growth rate is unpredictable. The present Hadoop relies on secondary namenode for failover which slows down the performance of the system. Hadoop system’s scalability depends on the ve...

BACKGROUND Increased levels of interferon (IFN)-inducible IFI16 protein (encoded by the IFI16 gene located at 1q22) in human normal prostate epithelial cells and diploid fibroblasts (HDFs) are associated with the onset of cellular senescence. However, the molecular mechanisms by which the IFI16 protein contributes to cellular senescence-associated cell growth arrest remain to be elucidated. Her...

The combination of Hadoop and HDFS is becoming a defacto standard system in handling big data. HDFS is a distributed file system that is designed for big data. In HDFS, a file consists of multiple large sized blocks. A central management of HDFS tries to scatter these multiple blocks on different nodes to maximize the I/O throughput. Hadoop is a framework that supports data intensive parallel a...

BACKGROUND Genistein, as an active compound of dietary antioxidants, has shown considerable promise as an effective agent against aging process. However, the effect of genistein on skin photoaging and the associated mechanism remain unclear. OBJECTIVE To delineate the effect of genistein on UVB-induced senescence in human dermal fibroblasts (HDFs) with emphasis on the mechanism of oxidative p...

In human diploid fibroblasts (HDFs), expression of lamina-associated polypeptide 2 alpha (LAP2alpha) upon entry and exit from G(0) is tightly correlated with phosphorylation and subnuclear localization of retinoblastoma protein (Rb). Phosphoisoforms of Rb and LAP2alpha are down-regulated in G(0). Although RbS780 phosphoform and LAP2alpha are up-regulated upon reentry into G(1) and colocalize in...

The Hadoop Distributed File System (HDFS) scales to store tens of petabytes of data despite the fact that the entire le system's metadata must t on the heap of a single Java virtual machine. The size of HDFS' metadata is limited to under 100 GB in production, as garbage collection events in bigger clusters result in heartbeats timing out to the metadata server (NameNode). In this paper, we addr...

Oral mucosa is a useful material for regeneration therapy with the advantages of its accessibility and versatility regardless of age and gender. However, little is known about the molecular characteristics of oral mucosa. Here we report the first comparative profiles of the gene signatures of human oral mucosa fibroblasts (hOFs), human dermal fibroblasts (hDFs), and hOF-derived induced pluripot...