Human diploid fibroblasts (HDF) complete a limited number of cell divisions before entering a growth arrest state that is termed replicative senescence. Two histone deacetylase inhibitors, sodium butyrate and trichostatin A, dramatically reduce the HDF proliferative life span in a manner that is dependent on one or more cell doublings in the presence of these agents. Cells arrested and subseque...

BACKGROUND The Mucosal Atomization Device (MAD) distributes medication throughout the paranasal sinuses for patients with chronic rhinosinusitis (CRS). Determining the optimal head position is important to ensure maximal delivery of medication to the sinus cavities. The objective of this work was to determine the effect of the lying-head-back (LHB) and head-down and forward (HDF) position, on t...

background: acute blood purification (abp) therapy is used regularly in the clinical setting and reportedly alleviates organ failure associated with severe systemic inflammatory responses, leading to reduced mortality. the present study aimed to determine whether there is a difference in efficacy between polysulfone (ps) membranes, which are currently used regularly in the clinical setting, and...

Sir, On-line haemodiafiltration (HDF) is a technique that combines diffusion with elevated convection in which the substitution fluid is produced directly from the dialysate [1]. The safety of this technique in terms of sterility and nonpirogenicity has been confirmed by several studies [2,3]. The activation of inflammatory systems has been associated with both shortand long-term complications ...

We calculate the expected strong gravitational lensing rate in the Hubble Deep Field (HDF) by using photometric redshift information for galaxies present in all four HDF passbands with a I-band magnitude limit of 27. A comparison of these predictions with the observed number of strongly lensed sources places a lower limit on the current value of Ωm − ΩΛ, where Ωm is the cosmological mass densit...

We calculate the expected number of multiply-imaged galaxies in the Hubble Deep Field (HDF), using photometric redshift information for galaxies with mI < 27 that were detected in all four HDF passbands. A comparison of these expectations with the observed number of strongly lensed galaxies places a lower limit on the current value of Ωm − ΩΛ, where Ωm is the cosmological mass density of the un...

BACKGROUND Citrate has anticoagulative properties and favorable effects on inflammation, but it has the potential hazards of inducing hypocalcemia. Bicarbonate dialysate (BHD) replacing citrate for acetate is now used in chronic haemodialysis but has never been tested in postdilution online haemodiafiltration (OL-HDF). METHODS Thirteen chronic stable dialysis patients were enrolled in a pilot...

Chronic systemic inflammation and repetitive damage of vascular endothelia by incompatible dialysis system are probable causes of cardiovascular disease in patients on dialysis. The present study aimed to assess in vitro biocompatibility and anti-inflammatory effect of hemodialysis fluid supplemented with rosmarinic acid (RA) using human umbilical vein endothelial cells (HUVEC). HUVECs (5×106 c...

Introduction Calcium oxalate supersaturation is regularly exceeded in the plasma of patients with end-stage renal disease (ESRD). Previous reports have indicated that hemodialfiltration (HDF) lowers elevated plasma oxalate (POx) concentrations more effectively compared with hemodialysis (HD). We reevaluate the therapeutic strategy for optimized POx reduction with advanced dialysis equipment and...