We use a multifluid hydrodynamical-chemical model of cometary comae to predict the HNC and HCN abundances in comets Hyakutake and Hale-Bopp for a variety of initial parameters. We find, in general, that the presence of methanol in the nuclear ices inhibits the synthesis of HNC from HCN through proton transfer reactions in the coma. For Hale-Bopp, we find that because of the large gas production...

Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels underlie the cationic Ih current present in many neurons. The direct binding of cyclic AMP to HCN channels increases the rate and extent of channel opening and results in a depolarizing shift in the voltage dependence of activation. TRIP8b is an accessory protein that regulates the cell surface expression and dendritic local...

We present a search for HCN emission from four high redshift far infrared (IR) luminous galaxies. Current data and models suggest that these high z IR luminous galaxies represent a major starburst phase in the formation of spheroidal galaxies, although many of the sources also host luminous active galactic nuclei (AGN), such that a contribution to the dust heating by the AGN cannot be precluded...

We present here the sensitive HCN(1-0) observations made with the VLA of two submillimeter galaxies and two QSOs at high-redshift. HCN emission is the signature of dense molecular gas found in GMC cores, the actual sites of massive star formation. We have made the first detection of HCN in a submillimeter galaxy, SMM J16359+6612. The HCN emission is seen with a signal to noise ratio of 4σ and a...

The onset of spontaneous seizures in the pilocarpine model of epilepsy causes a hyperpolarized shift in the voltage-dependent activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel-mediated current (Ih) in CA1 hippocampal pyramidal neuron dendrites, contributing to neuronal hyperexcitability and possibly to epileptogenesis. However, the specific mechanisms by which spon...

Alteration in hydrocyanic acid potential (HCN-p) of the forage is one of the important objectives in sudangrass [Sorghum sudanense (Piper) Stapf] breeding programs. The effectiveness of recurrent phenotypic selection for increasing or decreasing HCN-p in sudangrass was evaluated in two cycles of individual plant selection in the cultivar 'Greenleaf. In cycle 1, HCNp means of the high and low po...

Currently hydrogen cyanide (HCN) is industrially produced in the Czech Republic (Lucebni zavody Draslovka Kolin) and is extensively used for Czech mill fumigation. Therefore we evaluated the potential of HCN fumigant for treatment of wooden transport packages (pallets). We tested the penetration of HCN trough wooden pallet materials using gas chromatography. The preliminary results on biologica...

The experiments seem to indicate that the toxicity of HCN and KCN for amebae is due to their effect on the cell membrane and not on the internal protoplasm. Concentrated solutions (N/10-N/300) of HCN or KCN produce an initial increase in viscosity of the protoplasm of amebae (immersed) which is followed by liquefaction and disintegration of the cell. Dilute solutions of HCN or KCN decrease the ...

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are reverse voltage-dependent, and their activation depends on the hyperpolarization of the membrane and may be directly or indirectly regulated by the cyclic adenosine monophosphate (cAMP) or other signal-transduction cascades. The distribution, quantity and activation states of HCN channels differ in tissues throughout the bod...

We detect HCN J=5-4 emission from the ultraluminous quasar APM08279+5255 at z=3.911 using the IRAM Plateau de Bure interfer-ometer. This object is strongly gravitationally lensed, yet still thought to be one of the most intrinsically luminous objects in the Universe. The new data imply a line luminosity L ′ HCN (J=5−4) = 4.0 ± 0.5 × 10 10 K km s −1 pc 2. The ∼ 440 km s −1 full width half maximu...