Background: Inflammatory cytokines are related to the occurrence and development of hepatocellular carcinoma (HCC). Objectives: Interleukin 6 (IL-6) is associated with prognosis HCC, while Dicer inhibits HCC; accordingly, we checked whether regulates HCC by modulating IL-6 pathway. Methods: The cells SMMC-7721 transfected overexpression (pCMV-Dicer) control (pCMV-NC) lentivirus were divided int...

Background Hepatocellular carcinoma (HCC) is a high-incidence and significant cause of cancer globally. HCC the world's third most common death-related sixth tumor. In HCC, various cellular signaling activated to ensure malignancy transformation, angiogenesis, metastasis. The efficient pathway in mitogen-activated protein kinase (MAPK), which controls regulates apoptosis. mutant k-ras gene led ...

The activation of hepatic stellate cells (HSCs) is the key event fibrosis. Furthermore, activated HSCs also play an important role in progression hepatocellular cancer (HCC). Bone morphogenetic protein 14 (BMP14) a member TGF-β/BMP superfamily. So far, most studies have analyzed BMP14 context bone and cartilage formation homeostasis. aim this study was to assess expression function liver fibros...

Discrimination of regenerative cirrhotic nodules of the liver (CN) from hepatocellular carcinoma (HCC) is sometimes difficult. We examined the utility of AgNOR staining in this context. Fifteen cases of HCC and 25 cases of CN were stained by AgNOR method and the mean AgNOR number for one hundred nuclei in each case was determined. There was a significant difference between the mean AgNOR c...

Hepatocellular carcinoma (HCC), the most common primary liver cancer, relies on formation of new blood vessel for growth and frequent intrahepatic extrahepatic metastasis. Therefore, it is important to explore underlying molecular mechanisms tumor angiogenesis HCC. Recently, microRNAs have been shown modulate angiogenic processes by modulating expression critical factors. However, potential rol...

Abstract Fatty acid-binding protein 5 (FABP5) is highly expressed in hepatocellular carcinoma (HCC) tissues and related to HCC progression. In this study, we analyzed the potential of serum FABP5 (sFABP5) as a tumor marker its clinical significance We compared sFABP5 concentration patients with (HCC group) that hepatitis without (hepatitis group). Moreover, measured expression levels resected (...

Successive current trials using immune response checkpoint blockade, the systemic therapy for progressive hepatocellular carcinoma (HCC) has shifted dramatically towards targeting tumor microenvironment (TME). Locoregional therapies (LRTs) like radiofrequency ablation (RFA)/rhizotomy, trans-arterial chemoembolization (TACE) and surgical resection in initial stages are critical. LRTs perform cru...

Qilian Huaji Decoction (QLHJD) is a mixture of 13 herbs. The aim this study to observe the efficacy QLHJD against hepatocellular carcinoma (HCC). H22 transplanted mouse models were established explore effect on HCC in vivo. QLHJD-containing serum (QCS) was prepared using traditional Chinese medicine pharmacology methods. After QCS treatment, cell proliferation, cycle and apoptosis HepG2 cells a...

Introduction: Hepatocellular carcinoma (HCC) is sixth common cancers worldwide and predominant in Asia and Africa. A number of evidence suggests a possible role of midkine (MDK) and α-fetoprotein (AFP) in the pathogenesis of hepatocellular carcinoma (HCC). Materials and methods: We studied MDK and AFP in patients with HCC or in healthy controls. MDK and AFP was measured by enzyme linked immuno...