BACKGROUND Seroconversion rates reported after Hepatitis B virus (HBV) vaccination globally ranges from 85-90%. Health care workers (HCWs) are at high risk of acquiring HBV and non responders' rates after HBV vaccination were not reported previously in Pakistani HCWs. Therefore we evaluated immune response to HBV vaccine in HCWs at a tertiary care hospital in Karachi, Pakistan. METHODS Descri...

background: hepatitis b virus (hbv) infection causes chronic infection in human population, with high mortality. one of the high risk communities is mentally retarded children, who are institutionalized. special conditions in these centers predispose children for hbv infection and transmission to healthy people. in this study our objective was to determine the prevalence of hbv infection among ...

OBJECTIVE In thalassemic children, HBV infection is common, thus immunization against HBV will reduce and prevent the rate of infection. The aim of this study was to evaluate the efficacy of HBV immunization and the prevalence of HBV infection in beta-thalassemic children in Tehran. METHODS To assess the efficacy of immunization and determine the immune response of children with beta-thalasse...

HBV vaccination is recommend for hemodialysis patients, but only 50–60% of the patients show seroconversion. vaccine-induced generation reactive T and B cells could be detected regardless their capacity to mount a serological response, indicating that without seroconversion are potentially protected by HBV-reactive cell pool.

BACKGROUND Hepatitis B virus (HBV) infection is an endemic infection in Nigeria. Health care workers (HCWs) are at risk of occupational exposures to HBV-infected blood and body fluids. OBJECTIVE To determine the prevalence and determinants of HBV vaccine coverage among HCWs in two teaching hospitals in Nigeria. METHODS This cross-sectional study was undertaken in 2011 and 2012 in two teachi...

Data on hepatitis B virus (HBV) vaccine–induced cell-mediated immunity (CMI) and humoral immune response during infancy is scarce. We assessed HBV vaccine–induced CMI among infants stratified as nonresponders (Ab against HBV surface Ag [anti-HBs] levels ,10 IU/l), low-responders (anti-HBs levels 10–100 IU/l), and high-responders (anti-HBs levels $100 IU/l) following their primary vaccination ag...

BACKGROUND It is known that the immunogenicity of hepatitis B virus (HBV) vaccine is lower in uremic patients than healthy subjects. Numerous inherited or acquired factors have been implicated in this lowered response, and the high frequency of recombinant human erythropoietin use among patients on maintenance dialysis has been suggested to play a pivotal role. However, the impact of therapy wi...

BACKGROUND Hepatitis B virus (HBV) infection is a major global health burden with distinct geographic public health significance. Oman is a country with intermediate HBV carrier prevalence; however, little is known about the incidence of HBV variants in circulation. We investigated the HBV genotype distribution, the occurrence of antiviral resistance, and HBV surface antigen (HBsAg) escape muta...

BACKGROUND Liver cancer is the second most-frequent cause of cancer death in Korea. Hepatitis B virus (HBV) infection is a major cause of liver cancer, and this disease is effectively prevented by HBV vaccination. This study was conducted to investigate factors associated with the lack of HBV vaccine uptake in the general adult male population in Korea. METHODS Data of men who participated in...