chronic hepatitis b is still a major public health issue despite the successful prophylactic vaccination attempts. chronicity of hepatitis b virus(hbv) is mainly due to its ability to debilitate host's immune system. therefore, major measures have been taken to stop this process and help patients with chronic hepatitis b infection recover from their illness. while satisfactory results have...

The hepatitis B virus (HBV) envelope protein (S) self-assembles into subviral particles used as commercial vaccines against hepatitis B. These particles are excellent carriers for foreign epitopes, which can be inserted into the external hydrophilic loop or at the N- or C-terminal end of the HBV S protein. We show here that the N-terminal transmembrane domain (TMD) of HBV S can be replaced by t...

we read with a great interest the article written by davoodbeglou and colleagues entitled “evaluation of hepatitis b infection prevalence in institutionalized intellectually disabled children” which is recently published in your prestigious journal 1 . the authors concluded that hbv infection is more prevalent among institutionalized disabled children and that we should change our health polici...

context hepatitis b virus expanded program on immunization (epi) started on 1993 in iran. most surveys have assessed the level of response to vaccine by measuring the titers of anti-hbs. this meta- analysis aimed to summarize the iranian published data on the rate of vaccine-responders versus non-responders. moreover, the impact of variables such as age, gender, type of vaccine, etc. on the lev...

Recently, it was suggested that maternal hepatitis B surface antigen antibodies (anti-HBs) acquired transplacentally could play a negative role in newborn infants' immune response to the hepatitis B vaccine. We compared the hepatitis B virus (HBV) vaccine response in infants born to mothers previously vaccinated against HBV (n = 91) to infants born to mothers who were not previously vaccinated ...

Patients with autoimmune hepatitis (AIH) are a group at risk of disease exacerbation or relapse of the underlying disease should they fall ill with infectious hepatitis A (HAV) or B (HBV). Therefore, it seems appropriate to protect this group of persons against HAV and HBV disease by vaccination. An open study evaluated the safety, reactogenicity and immunogenicity of a combined HAV and HBV vac...

Chronic hepatitis B infection (CHB) is characterized by sub-optimal T cell responses to viral antigens. A therapeutic vaccine capable of restoring these immune responses could potentially improve HBsAg seroconversion rates in the setting of direct acting antiviral therapies. A yeast-based immunotherapy (Tarmogen) platform was used to make a vaccine candidate expressing hepatitis B virus (HBV) X...

Background. Hepatitis B virus (HBV) infection is a well recognised occupational health hazard preventable by vaccination. Objectives. To determine the knowledge of operating room personnel (ORP) in Nigeria about the Hepatitis B vaccine, their perception of Hepatitis B vaccination and vaccination status against HBV. Methods. Four university hospitals were selected by simple random sampling. A st...

INTRODUCTION Vaccination is the most effective tool in preventing transmission of Hepatitis B Virus (HBV). The patient with chronic kidney disease (CKD) on dialysis appear to be at greater risk of becoming infected with this virus and does not show the same vaccine response when compared to patients without uremia. OBJECTIVES To evaluate the results related to the HBV vaccine and identify fac...

Many Vaccine Information Statements are available in Spanish and other languages. See www.immunize.org/vis. 1 What is hepatitis B? Hepatitis B is a serious disease that affects the liver. It is caused by the hepatitis B virus (HBV). HBV can cause: Acute (short-term) illness. This can lead to: • loss of appetite • diarrhea and vomiting • tiredness • jaundice (yellow skin or eyes) • pain in muscl...