We have previously developed a genetically-engineered GFP-expressing telomerase-dependent adenovirus, OBP-401, which can selectively illuminate cancer cells. In the present report, we demonstrate that targeting a triple-negative high-invasive human breast cancer, orthotopically-growing in nude mice, with OBP-401 enables curative fluorescence-guided surgery (FGS). OBP-401 enabled complete resect...

Two issues may have a tremendous impact on the adequacy of retirement income for American workers. The first is the growth of 401(k) pension plans, which allow participants to contribute, before taxes, a portion of their salary to a qualified retirement account.1 By 1998, the most recent year that published information is available, 401(k) plans accounted for about 41 percent of all pension pla...

This is especially true in smaller companies and those of fairly recent vintage because 401(k)s are likely to be the only retirement program offered in these organizations. But, even in large and old-line businesses in which traditional defined benefit (DB) pension plans remain common, it’s important for employees to take responsibility for their retirement planning and save for retirement in o...

A sensitive and selective method was developed for the separation and characterization of related substances (RSs) in EVT-401 by hyphenated LC-MS techniques. Complete separation of the RSs was achieved with an Inertsil ODS-SP column (250 mm×4.6 mm, 5 µm) by linear gradient elution using a mobile phase consisting of 0.2% formic acid solution, methanol and acetonitrile. EVT-401 was found to be su...

this study carried out to evaluate the effect of different tillage systems on rapeseed yield (hayola 401) planted in corn residues. this experiment was done in moghan region with clay soils during 2009-2012. different seedbed preparation methods include mt: moldboard + disk tillage (conventional tillage was included), sct: stem crusher + chisel + disk tandem harrow, stt: stem crusher + double-d...

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Malignant melanoma requires precise resection in order to avoid metastatic recurrence. We report here that the telomerase-dependent, green fluorescent protein (GFP)-containing adenovirus OBP-401 could label malignant melanoma with GFP in situ in orthotopic mouse models. OBP-401-based fluorescence-guided surgery (FGS) resulted in the complete resection of malignant melanoma in the orthotopic mod...

By comparing 401(k) eligible and ineligible households’ wealth, this paper estimates that, on average, about one half of 401(k) balances represent new private savings, and about one quarter of 401(k) balances represent new national savings. Responses to eligibility vary considerably, however, with households who normally save the most largely contributing funds they would have saved anyway. Thi...

Within a …eld experiment, I present a treatment group with reductions in information, administrative, stigma and procrastination costs associated with the Advance EITC. The treatment only increases Advance participation from 0.3 to 1.2 percent. Another treatment simultaneously encourages 401(k) savings, increasing 401(k) participation from 46 to 50 percent. However, there is no additional incre...