نتایج جستجو برای: haplotyping

تعداد نتایج: 559  

Journal: :Journal of Computational Biology 2006

2012
Jorge Duitama Gayle K. McEwen Thomas Huebsch Stefanie Palczewski Sabrina Schulz Kevin Verstrepen Eun-Kyung Suk Margret R. Hoehe

Determining the underlying haplotypes of individual human genomes is an essential, but currently difficult, step toward a complete understanding of genome function. Fosmid pool-based next-generation sequencing allows genome-wide generation of 40-kb haploid DNA segments, which can be phased into contiguous molecular haplotypes computationally by Single Individual Haplotyping (SIH). Many SIH algo...

Journal: :Proceedings of the National Academy of Sciences 2013

2002
Jacob Odeberg Kristina Holmberg Per Eriksson Mathias Uhlén

Several million SNPs have been identified and are available in the public databases. For most, no effect on gene function or expression is known. “Functional polymorphisms” refers to SNPs to which a putative effect on gene function or expression is attributed and implies that they are “non-silent” variations located in regions that are coding, regulatory, splice sites, or untranslated regions t...

2008
Dan Gusfield Luonan Chen Jun Wang

Combinatorial Optimization is a central sub-area in Operations Research that has found many applications in computational biology. In this talk I will survey some of my research in computational biology that uses graph theory, matroid theory, and integer linear programming. The biological applications come from haplotyping, the study of recombination and recombination networks, and phylogenetic...

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