User interfaces (UI) of desktop, web, and mobile applications involve a hierarchy objects (e.g., applications, screens, view class, other types design objects) with multimodal textual visual) positional spatial location, sequence order, level) attributes. We can therefore represent set application UIs as heterogeneous network Such not only represents how users understand the visual layout but a...

The four transmembrane chemoreceptors of Escherichia coli sense phenol as either an attractant (Tar) or a repellent (Tap, Trg, and Tsr). In this study, we investigated the Tar determinants that mediate its attractant response to phenol and the Tsr determinants that mediate its repellent response to phenol. Tar molecules with lesions in the aspartate-binding pocket of the periplasmic domain, wit...

Motile prokaryotes use a sensory circuit for control of the motility apparatus in which ligand-responsive chemoreceptors regulate phosphoryl flux through a modified two-component signal transduction system. The chemoreceptors exhibit a modular architecture, comprising an N-terminal sensory module, a C-terminal output module, and a HAMP domain that connects the N- and C-terminal modules and tran...

Introduction: COVID-19 is a new type of coronavirus that infects humans and causes severe acute respiratory syndrome (SARS). Isolated in Wuhan City, China, December 2019. Similar to discoveries relating the coronaviruses cause (SARS-CoV) Middle East (MERS-CoV). Levels cytokines (Interleukin-6, Interleukin-1 β ), iron hemoglobin changed during disease. Hepcidin an regulatory protein encoded by H...

This paper studies the Homeowner Affordability Modification Program (HAMP), a 2009 federal program reducing delinquent homeowners mortgage payments to 31 percent of monthly income. To assess the program I propose and estimate a structural model of mortgage default using program results. The model allows for income, house prices, and exit preference shocks to induce default, and allows homeowner...

One of the major and essential classes of transmembrane (TM) receptors, present in all domains of life, is sensor histidine kinases, parts of two-component signaling systems (TCSs). The structural mechanisms of TM signaling by these sensors are poorly understood. We present crystal structures of the periplasmic sensor domain, the TM domain, and the cytoplasmic HAMP domain of the Escherichia col...

To find out whether the Interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is involved in the expression of hepcidin in the mouse brain in vivo, we investigated the phosphorylation of STAT3, as well as the expression of hepcidin mRNA, ferroportin 1 (Fpn1) and ferritin light chain (Ft-L) proteins in the cortex and hippocampus of LPS-treated wild typ...

Juvenile hereditary hemochromatosis is a genetically heterogeneous disorder transmitted as an autosomal recessive trait. It is most often caused by mutations in the HJV gene and rarely in the HAMP gene. Hepcidin is considered to constitute a negative regulator of iron absorption, and its production is increased in inflammatory states and iron overload. We report the detection of a new mutation ...

With the start of the parallel computing era, due to power and thermal considerations, there is a growing need to bridge the gap between parallel hardware and software. The unintuitive nature of parallel programming and the high learning curve often prove a bottleneck in the development of quality parallel software. We propose HAMP – A Highly Abstracted and Modular Programming paradigm for expr...

Gastric cancer is one of the most common malignancies with high cancer-associated mortality rate globally. Hepcidin is the peptide hormone, which is critically important in the regulation of systemic iron homeostasis. Cumulating evidence has reported that the disturbed local expression of hepcidin may serve as a predictive biomarker in assessing the clinical outcomes in a range of cancer types....