natural sources of water contain some halogenated organic compounds after disinfection by chlorine. trihalomethanes are one group of the chlorination by products that suspected of being carcinogenic inhuman unfortunately, these compounds are in finished water of all treatment plants that use chlorine as a disinfectant. in this study, the concentration of total thms of water treated in the water...

Unusual 2,7-diazacarbazoles were prepared in one step from readily available tetra-halogenated 4,4'-bipyridines by using a double N-arylation reaction in the presence of the Pd-XPhos catalyst system. Moderate to good yields were obtained in this site-selective Buchwald-Hartwig double amination. The functionalization of these tricyclic derivatives was performed by using Pd-catalyzed cross-coupli...

[structure: see text]. Halogen functional groups on pentacene can be used both as synthetic handles for further functionalization as well as to tune the pi-stacking in these systems. The halogenated pentacene derivatives described here (X = Br, X' = H, and X = X' = F) are all stable and soluble, with reduction potentials significantly lower than that of the parent functionalized pentacene (X = ...

The discovery of the therapeutic properties of certain steroids has recently given rise to interesting chemical and pharmacological problems. The remarkable antiphlogistic activities of halogenated derivatives of hydrocortisone, and the disappearance of secondary effects obtained by the A1-diene derivatives of cortisone, have suggested the synthesis of a steroid which joins the two chemical cha...

Three man synthetic routes to analogues of tacrine are described: reaction of anthranilonitriles with cyclohexanone and other ketones, reaction of various anilines with alpha-cyanoketones, and reactions involving anilines and cyclic beta-ketoesters. Although tacrine has a wide range of pharmacological effects, it is best known as an inhibitor of cholinesterase enzymes. Many of the analogues tha...

Thymidine monophosphate kinase (TMPK) from Mycobacterium tuberculosis (TMPKmt) is an attractive target for the design of specific inhibitors. This fact is the result of its key role in the thymidine pathway and of unique structural features in the active site observed by X-ray crystallography, especially in comparison to its human counterpart (TMPKh). Different 5-modified thymidine derivatives,...

It was suggested some years ago that P-oxidation of nitrosodi-n-propylamine might play a part in the carcinogenic action of this compound (Pour eta/., 1975). So far there has been no indication that this is so from the tests of two P-oxidized ·derivatives, nitrosobis(2-hydroxypropyl)amine and nitrosobis(2-oxypropyl)amine, in Syrian golden hamsters (Kriiger et al., 1974; Pour et al., 1977), in w...

Chlorinated guaiacol derivatives are found in waste water of pulp mills using chlorine in the bleaching process of wood pulp. They can also be detected in fish tissue, possibly causing off-odors. To date, there is no systematic investigation on the odor properties of halogenated guaiacol derivatives. To close this gap, odor thresholds in air and odor qualities of 14 compounds were determined by...

The lithiation of halogenated azobenzenes by halogen-lithium exchange commonly leads to substantial degradation of the azo group to give hydrazine derivatives besides the desired aryl lithium species. Yields of quenching reactions with electrophiles are therefore low. This work shows that a transmetalation reaction of easily accessible stannylated azobenzenes with methyllithium leads to a near-...