Massive haemorrhage still accounts for up to 40% of mortality after traumatic injury. The importance of limiting blood loss after injury in order to prevent its associated complications has led to rapid advances in the development of dressings for haemostatic control. Driven by recent military conflicts, there is increasing evidence to support their role in the civilian prehospital care environ...

Before a new method is used for clinical testing, it essential that evaluated suitability its intended purpose. This document gives guidance the performance, verification and implementation processes required by regulatory accreditation bodies. It covers planning of specialist haemostatic tests, including factor assays, D-dimers, direct anticoagulants thrombophilia testing.

The haemostatic mechanism was investigated in 20 patients with renal failure, of whom nine had evidence of a bleeding tendency. A defect of platelet function was the most common finding. The effect of dialysis on the bleeding state is briefly discussed, and a scheme for the routine investigation of haemostasis in renal failure is put forward.

Skilful surgery combined with blood-saving methods and careful management of blood coagulation will all help reduce unnecessary blood loss and transfusion requirements. Excessive surgical bleeding causes hypovolaemia, haemodynamic instability, anaemia and reduced oxygen delivery to tissues, with a subsequent increase in postoperative morbidity and mortality. The role of anaesthetists in managin...

Differences in genetic influence on death from CHD between males and females have been reported. Haemostatic factors have consistently been associated with risk for coronary heart disease (CHD), but sex differences in genetic architecture have not been studied. This study in middle-aged twins investigates whether there are sex differences in means and in genetic and/or environmental variance co...

OBJECTIVE Post-operative neurosurgical patients are commonly associated with haemostatic derangements; many a times leading to development of overt disseminated intravascular coagulation (DIC) and eventually death in some of them. The present study has analysed the factors that would predict the outcome in post operative neurosurgical patients with deranged haemostatic parameters. METHODS Thi...

background the aim of the present study was to compare two analgesic techniques for transrectal ultrasound (trus)-guided biopsy: diclofenac patch versus periprostatic nerve block with 1% lidocaine. objectives to study the efficacy of and compare diclofenac patch and periprostatic nerve block as analgesia in trus-guided prostate needle biopsy. patients and methods in total, 60 patients were pros...