The demand for blood products containing factor VIII for treating patients with haemophilia A in south-east Scotland was reviewed. From 1961 to 1975 the demand for fresh frozen plasma (FFP), cryoprecipitate (CP), and antihaemophilic factor (AHF) increased by seven and a half times, while total donations increased by only a third. Patients with severe haemophilia A treated at the regional haemop...

Haemophilia is a congenital coagulation disorder characterized by uncontrolled haemorrhagic episodes that are crippling and potentially life-threatening. Haemophilia A results from subnormal levels of an essential cofactor protein, factor VIII (F.VIII), and affects 1 in every 10,000 males; haemophilia B is associated with a lack of an essential protease, factor IX (F.IX), and occurs in 1 out of...

Acquired haemophilia A is a serious and potentially fatal bleeding disorder. Diagnosis is difficult and maybe delayed due to its rarity. The high mortality rate and the complex nature of treatment necessitate patient management at a haemophilia centre, where the required expertise and resources are available. Prompt diagnosis is crucial and early initiation of therapy could be life saving. Mana...

As a result of safer blood products and more effective treatments for human immunodeficiency virus (HIV) and hepatitis C infection (HCV), the life expectancy of those with haemophilia is approaching that of the general population. This was predicted over 20 years ago by Dutch epidemiologists who assessed the mortality of haemophilic men, after controlling for HIV and HCV infections (1). Thus, i...

A guide for the dental management of the three inherited bleeding disorders, von Willebrand's disease, haemophilia A and haemophilia B, was established jointly by the Institute of Medical and Veterinary Science Transfusion and Haemostasis Unit in conjunction with the Medically Compromised Dental Unit at the Adelaide Dental Hospital. This protocol was subjected to a successful trial for 24 months.

A family is described in which the mother is a haemophilia carrier, the father has asymptomatic type IIA von Willebrand's disease, and their second son has simultaneously inherited both severe haemophilia and type IIA von Willebrand's disease. This is the first report of both diseases occurring simultaneously. The inheritance patterns and laboratory data on the family are presented and discussed.

Haemophilia is an inherited disorder of the body's blood clotting mechanism. Past treatments have led to the transmission of blood-borne viruses, primarily HIV and hepatitis C. Current clotting factor concentrates and treatment regimes offer patients a good quality of life. Specialist haemophilia nurses play a pivotal role in the organisation and delivery of care to this patient group.

A case of pseudotumour of the left ankle in a twenty year old Malay with severe Haemophilia A, who defaulted treatment for one year, and another in the left gluteal region in a thirty eight year old Chinese with severe Haemophilia A are reported. Both cases which developed complications of pseudotumours, demonstrate the importance of early and adequate treatment of muscle bleeds in haemophiliacs.

Haemophilia is a heredity disorder in which bleeding is due to deficiency of coagulation factor VIII. Haemophilia A is the second most common inherited coagulation disorder. Estimation of its incidence ranges from 1 in 20,000 to as high as 1 in 10,000 people. It is a classic example of x-linked recessive trait (1). The frequency and severity generally are related to the blood level of factor VI...