We read with great interest the Highlight Review by Dr C GruÈ ndker entitled `Cytotoxic luteinizing hormonereleasing hormone conjugates and their use in gynecological cancer therapy' in the European Journal of Endocrinology (1). This excellent article provides a detailed description of recent developments in the field of targeted chemotherapy based on luteinizing hormone-releasing hormone (LH-R...

Recently, we developed a series of cytotoxic peptide conjugates containing 14-O-glutaryl esters of doxorubicin (DOX) or 2-pyrrolino-DOX (AN-201). Serum carboxylesterase enzymes (CE) can partially hydrolyze these conjugates in the circulation, releasing the cytotoxic radical, before the targeting is complete. CE activity in serum of nude mice is about 10 times higher than in human serum. Thus, w...

having briefly been reviewed the historical process of changing the formulae for determining the times of islamic prayers, two newly found formulae and a new rule for establishing the times of prayers would be discussed. these matters have been exploited from four texts, still preserved as manuscript: (1) siyyid ¾?y? al-d?n sh?shtar?’s ¼ad b?b dar macrifa al-a½??rl?b, (2) b?r?n?’s ’ist?c?b f? c...