نتایج جستجو برای: h22

تعداد نتایج: 370  

2017
Wenxi Wang Anna Shao Nan Zhang Jinzhang Fang Jennifer Jin Ruan Benfang Helen Ruan

Liposome (LP) encapsulation of doxorubicin (DOX) is a clinically validated method for cancer drug delivery, but its cellular uptake is actually lower than the free DOX. Therefore, we modified DOX-LP with a cationic polymer (Eudragit RL100; ER) to improve its cellular uptake and antitumor activity. The resulting DOX-ERLP was a 190 nm nanoparticle that was absorbed efficiently and caused cancer c...

Journal: :Molecular medicine reports 2015
Jing Li Ou Li Mujie Kan Ming Zhang Dan Shao Yue Pan Huilin Zheng Xuewen Zhang Li Chen Songyan Liu

Berberine (BBR) has been suggested as a potential candidate anticancer agent due to its high anticancer activity and multiple mechanisms. In the present study, the inhibitory effect of BBR on hepatocellular carcinoma (HCC) via the suppression of the arachidonic acid (AA) metabolic pathway was investigated. BBR was demonstrated to reduce the viabilities of H22, HepG2 and Bel‑7404 cells, in a dos...

2013
Sonja Schiffer Radoslav Mladenov Eric Aslanian Michael Huhn Rainer Fischer Stefan Barth Theo Thepen

Human cytolytic fusion proteins (hCFPs) are comprised of a specific cell-surface-binding moiety and an effector molecule of human origin. In contrast to common immunotoxins, including bacterial or plant toxins, they are considered not to be immunogenic. Two examples for human pro-apoptotic effector proteins are the serine protease Granzyme B and the RNase Angiogenin. Pre-clinical testing of fun...

Journal: :Evidence-Based Complementary and Alternative Medicine 2015

Journal: :Molecules 2012
Yi Bi Jinyi Xu Fei Sun Xiaoming Wu Wencai Ye Yijun Sun Wenwen Huang

23-Hydroxybetulinic acid (1) served as the precursor for the synthesis of C-28 ester derivatives. The target compounds were evaluated in vitro for their antitumor activities against five cell lines (A549, BEL-7402, SF-763, B16 and HL-60). Among the obtained compounds, 6i had the most potent antitumor activity, with the IC(50 values of 8.35 µM in HL-60 cells and showed similar antitumor activity...

Journal: :American Economic Journal: Economic Policy 2021

We study the geographic incidence and efficiency of an income tax by estimating a spatial equilibrium model with heterogeneous workers. The US shifts households out high-productivity cities, leading to locational inefficiency 0.25 percent output. Removing distortions increases inequality because more educated are mobile own larger shares land. Flattening schedule, or introducing cost-of-living ...

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