PURPOSE To determine the concentrations of methylglyoxal-derived advanced glycation end-products (AGEs), the hydroimidazolones MG-H1 and -H2, in soluble human lens proteins and compare them with the concentrations of other methylglyoxal-derived AGEs and pentosidine. METHODS Lens protein samples were hydrolyzed enzymatically. AGEs were assayed without derivatization by HPLC with tandem mass sp...

Following a bout of dynamic exercise, humans experience sustained postexercise vasodilatation in the previously exercised skeletal muscle which is mediated by activation of histamine (H1 and H2) receptors. Skeletal muscle glucose uptake is also enhanced following dynamic exercise. Our aim was to determine if blunting the vasodilatation during recovery from exercise would have an adverse effect ...

Abstract All extant purely probabilistic measures of explanatory power satisfy the following technical condition: if Pr(E | H1) > H2) and ∼H1) < ∼H2), then H1’s with respect to E is greater than H2’s E. We argue that any measure satisfying this condition faces three serious problems—the Problem Temporal Shallowness, Negative Causal Interactions, Nonexplanations. further many such face a f...

AIM To explore the role of the ACE gene polymorphisms in the risk of essential hypertension in Mexican Mestizo individuals and evaluate the correlation between these polymorphisms and the serum ACE levels. METHODS Nine ACE gene polymorphisms were genotyped by 5' exonuclease TaqMan genotyping assays and polymerase chain reaction (PCR) in 239 hypertensive and 371 non- hypertensive Mexican indiv...

GABA(B) receptors assemble from principle and auxiliary subunits. The principle subunits GABA(B1) and GABA(B2) form functional heteromeric GABA(B(1,2)) receptors that associate with homotetramers of auxiliary KCTD8, -12, -12b, or -16 (named after their K(+) channel tetramerization domain) subunits. These auxiliary subunits constitute receptor subtypes with distinct functional properties. KCTD12...

The role of endogenous histamine and H1, H2 and H3 central receptors on food intake in broiler chickenswas investigated. For this purpose, a probe was used to manipulate the concentration of endogenoushistamine by intracerebroventricular (ICV) injection of thioperamide, an H3 receptor antagonist, and R-α-methylhistamine, an H3 receptor agonist and subsequently the effects of brain histaminergic...

The effects of both an H1 receptor antagonist and an H2 receptor antagonist on changes in monovalent ion flux induced by topical sodium taurocholate were studied in antrectomised dogs fashioned with a denervated fundic pouch. The magnitude of taurocholateinduced ion flux was unaffected by topical administration of H1 or H2 receptor antagonists. Parenteral administration of H1 or H2 receptor ant...

Given a graph H with vertices w1, . . . , wm, a graph G with at least m vertices is H-linked if for every choice of vertices v1, . . . , vm in G, there is a subdivision of H in G such that vi is the branch vertex representing wi (for all i). This concept generalizes the notions of k-linked, k-connected, and k-ordered graphs. For graphs H1 and H2 with the same order that are not contained in sta...