A literature review has shown that the daily intakes of various N-nitroso-precursor classes in a typical European diet span five orders of magnitude. Amides in the form of protein, and guanidines in the form of creatine and creatinine, are the nitrosatable groups found most abundantly in the diet, approaching levels of 100 g/day and 1 g/day, respectively. Approximately 100 mg of primary amines ...

The class Echinoidea assumed prominence in the field ofcomparative biochemistry when it was shown by Needham, Needham, Baldwin & Yudkin (1932) that the jaw muscles of Strongylocentrotus lividus contained both phosphocreatine and phosphoarginine. Further work by Baldwin & Needham (1937) showed that extracts of the jaw muscles of two other echinoids, Paracentrotus lividu,s and Sphaerechinus granu...

A straightforward approach to novel 2-dialkylamino-4H-pyrido[1,2-a][1,3,5]triazin-4-ones synthesis is presented. The construction of these compounds was achieved by one-pot involving condensation 2-aminopyridine or 2-aminopicolines with ethoxycarbonylisothiocianate, followed amination the thioureas, and finally thermal ring closure resulting guanidines. This allowed access unreported title hete...

2-Aminobenzimidazole 10, although a weak catalyst in the monomeric state, is successful building block for effective artificial ribonucleases. In an effort to identify new blocks with improved catalytic potential, RNA cleavage by variety of heterocyclic amidines and guanidines has been studied. addition pKa values steric effects, energy difference between tautomeric forms seems be another impor...

From organosuperbases capable of base-catalyzing organic reactions, through versatile 'ligand-sets' for use in coordination chemistry, to fundamental entities in medicinal chemistry, guanidines are amongst the most interesting, attractive, valuable, and versatile organic molecules. Since the discovery of these compounds, synthetic chemists have developed new methodologies that are mainly based ...

The first iron-catalyzed guanylation of amines is reported. Commercially available Fe(OAc)2 acts as an excellent catalyst for the addition of amines to carbodiimides. The reaction is broadly applicable to a variety of primary, secondary, and heterocyclic amines, and tolerates a wide range of functionalities allowing the easy preparation of a large family of guanidines. The low price and low tox...

The widespread application of cell penetrating agents to clinical therapeutics and imaging agents relies on the ability to prepare them on a large scale and to readily conjugate them to their cargos. Dendritic analogues of cell penetrating peptides, with multiple guanidine groups on their peripheries offer advantages as their high symmetry allows them to be efficiently synthesized, while orthog...