Children with left-to-right shunt, with and without congestive heart failure, were found to have impaired glucose tolerance tests (GTT). In cyanotic children normal levels of glucose were found in association with abnormally high levels of insulin following oral GTT. Several possible mechanisms are proposed to explain the different glucose tolerance alterations: (1) Suppression of insulin relea...

OBJECTIVES Record review is the most used method to quantify patient safety. We systematically reviewed the reliability and validity of adverse event detection with record review. DESIGN A systematic review of the literature. METHODS We searched PubMed, EMBASE, CINAHL, PsycINFO and the Cochrane Library and from their inception through February 2015. We included all studies that aimed to des...

OBJECTIVE To determine which physiological variables conduce to walking intolerance in patients with peripheral arterial disease (PAD). DESIGN The physiological response to a graded treadmill exercise test (GTT) in patients with PAD was characterised. SETTING Patients were recruited from the Department of Vascular Surgery, Groote Schuur Hospital, Cape Town. SUBJECTS Thirty-one patients di...

BACKGROUND Arterial distensibility measures, generally from pulse-wave velocity (PWV), are widely used with little knowledge of relationships to patient outcome. We tested whether aortic PWV predicts cardiovascular and all-cause mortality in type 2 diabetes and glucose-tolerance-tested (GTT) multiethnic population samples. METHODS AND RESULTS Participants were randomly sampled from (1) a type...

BACKGROUND Accumulating evidence has shown an increased risk of type 2 diabetes in general populations exposed to arsenic, but little is known about exposures during pregnancy and the association with gestational diabetes (GD). OBJECTIVES We studied 532 women living proximate to the Tar Creek Superfund Site to investigate whether arsenic exposure is associated with impaired glucose tolerance ...

Children with left-to-right shunt, with and without congestive heart failure, were found to have impaired glucose tolerance tests (GTT). In cyanotic children normal levels of glucose were found in association with abnormally high levels of insulin following oral GTT. Several possible mechanisms are proposed to explain the different glucose tolerance alterations: (1) Suppression of insulin relea...

OBJECTIVE The aim of the study was to identify the incidence, diagnosis, therapeutic and histological particularities of molar pregnancies and to evaluate our management of gestational trophoblastic tumors (GTT) according to the recommendations of FIGO. METHODS This was a retrospective study of 90 patients who were diagnosed with molar pregnancy from January 1991 to December 2007. After remis...

RATIONALE Hereditary hemochromatosis can be divided into HFE- and non-HFE-related based on genetic mutations in different genes. HFE-related hemochromatosis is the most common inherited genetic disease in European populations but rare in Asia-pacific region. Recently, non-HFE-related hemochromatosis has been reported in patients from the Asian countries. PATIENT CONCERNS We report the case of...

Background Recently with the improvement of people’s living standards, eating fine, irregular life, lack of exercise and increased mental stress, the incidence of constipation is increasing. Gastrointestinal (GI) tract’s pressure information can reflect the dynamic disorder of gastrointestinal physiological and pathological changes, which is important in early diagnosis and treatment of constip...