Background The Cancer Immunotherapy Trials Network has initiated several clinical trials utilizing T cell growth factors such as IL-15 and IL-7. In support of these trials, we have developed and conducted precision testing of a 12-color flow cytometric assay to characterize the surface markers present on T cells in fresh whole blood and among cryopreserved peripheral blood mononuclear cells (PB...

This study aimed to assess whether repetitive intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) cause sustained elevation of intraocular pressure (SE-IOP). We conducted a systematic review and meta-analysis based on five randomized controlled trials (RCTs) assessing 1428 subjects and 17 non-RCTs evaluating 8358 cases. In the RCTs, an increased risk of SE-IOP w...

introduction: diarrheal diseases are a serious health problem and important causes of growth retardation and death in the developing world, especially those of prolonged duration. since diarrhea is constantly found in children with zinc deficiency, very studies supported zinc supplements beneficial on the duration and severity of diarrhea among children. we review the impact of zinc effects on ...

Pathological vessel growth harms vision and may finally lead to loss. Anti-angiogenic gene therapy with viral vectors for ocular neovascularization has shown great promise in preclinical studies. Most of the studies have been conducted different adeno-associated serotype vectors. In addition, adeno- lentivirus used. Therapy targeted towards blocking vascular endothelial factors or other pro-ang...

to identify the antidiabetic plants of iran, a systematic review of the published literature on the efficacy of iranian medicinal plant for glucose control in patients with type 2 diabetes mellitus was conducted. we performed an electronic literature search of medline, science direct, scopus, proquest, ebsco, googlescholar, sid, cochrane library database, from 1966 up to june 2010. the search t...

obtaining informed consents is one of the most fundamental principles in conducting a clinical trial. in order for the consent to be informed, the patient must receive and comprehend the information appropriately. complexity of the consent form is a common problem that has been shown to be a major barrier to comprehension for many patients. the objective of this study was to assess the readabil...

ethical consideration is a basic requirement for design of randomized clinical trials. the purpose of this study was to assess whether reports of iranian dental clinical trials complied with the requirements of the ethical principles of human research.in this retrospective observational study electronic search was performed to identify all dental clinical trials published between 2001 and 2011....

free radicals are produced continuously in the cells as part of normal cellular function, however excess production might play a role in pathophysiology of many disease conditions, including cancer, alzheimer's disease, atherosclerosis and some of the drug-induced toxicity. many basic research studies and observational epidemiologic studies in human suggest that antioxidants can prevent oxidati...

BACKGROUND There is no consensus regarding the effects on growth velocity of intranasal topical corticosteroid (ITC) use in children. The objective of this study was to determine whether ITC use reduces growth velocity in children with allergic rhinitis (AR). METHODS A literature search of the National Center for Biotechnology Information PubMed, EMBASE, SCOPUS, and Cochrane databases from Ja...