The role of nitric oxide in group B Streptococcus (GBS) infection was evaluated by inhibiting its production with aminoguanidine (AG). AG-treated mice displayed higher mortality rates and more frequent and severe arthritis than controls. Worsening of arthritis correlated with a higher number of GBS cells in the joints and local interleukin-1 beta production.

The R28 protein of group A streptococcus (GAS) and the Rib protein of group B streptococcus (GBS) are surface molecules that elicit protective immunity to experimental infection. These proteins are members of the same family and cross-react immunologically. In spite of extensive amino acid residue identity, the cross-reactivity between R28 and Rib was found to be limited, as shown by analysis w...

Introduction: The occurrence of urinary tract infections (UTIs) caused by the group B Streptococcus (GBS) in females is well documented. On the contrary, the prevalence amongst males is infrequent, and studies from the Indian subcontinent are limited. This study aimed to determine the occurrence of GBS bacteriuria and its antibiotic susceptibility profile amongst male patients. Methods: Clean-c...

Introduction: Group B streptococcus (GBS) or Streptococcus agalactiae can colonize the gastrointestinal and genitourinary tracts and has been considered one of the most important risk factors for the development of neonatal disease. The present study evaluated the antimicrobial susceptibility of GBS isolates from pregnant women who were attended at a public health service in Northern Paraná, Br...

Background: Signaling mediated by serine/threonine phosphatases during bacterial pathogenesis is not completely understood. Results: In Group B Streptococcus (GBS), Stp1 controls serine/threonine kinase function, posttranscriptional regulation of hemolysin, autolysis and virulence. Conclusion: Although not essential for growth, Stp1 is critical for GBS pathogenesis. Significance: The importance...

Group B streptococcus (GBS) serotypes causing neonatal disease vary by geographic region. Surveillance at the Brigham and Women's Hospital in Boston, Massachusetts, revealed a case of neonatal early-onset sepsis caused by type IV GBS. Neonatal type IV disease occurs in the Middle East but has not recently been described in U.S. infants.

Group B streptococcus (GBS) capsular serotypes are major determinants of virulence and affect potential vaccine coverage. Here we report a whole-genome-sequencing-based method for GBS serotype assignment. This method shows strong agreement (kappa of 0.92) with conventional methods and increased serotype assignment (100%) to all 10 capsular types.

Group B streptococcus (GBS) is the most common cause of neonatal infection in North America and is associated with morbidity and mortality. Prompt recognition and treatment of the infection is imperative. Diagnostic tests and treatment options vary, without clear research-based recommendations. Future trends should focus on GBS infection as a public health issue, with an emphasis on prevention.

An outbreak of invasive group B Streptococcus (GBS) disease occurred in Singapore in mid-2015. We conducted a case-control study of 22 adults with invasive GBS infections during June 21-November 21, 2015. Consumption of raw fish was strongly associated with invasive sequence type 283 infections, but not with non-sequence type 283 infections.

Cellulitis-adenitis syndrome is a well-known presentation of Group B Streptococcus (GBS) late-onset sepsis in children. Although face and neck are most frequently involved, other locations can also be affected. Inguinal presentation is uncommon, but it may be the first clinical manifestation of a GBS bacteremia. We present two cases of cellulitis-adenitis syndrome with inguinal involvement in t...