Introduction: Until the mechanics of anterior cruciate ligament (ACL) injuries and contributing factors are better elucidated, effective preventive strategies will continue to elude us. Current dogma is that ACL injury results from a single loading cycle, but recent evidence supports tissue fatigue as a possible failure mechanism [1]. In a cadaveric pivot landing model, ACL rupture was found to...

BACKGROUND Gaucher disease (GD) is a rare lysosomal storage disease caused by deficiency in the enzyme beta-glucocerebrosidase. Along with visceral, hematologic, and bone manifestations, patients may experience chronic fatigue resulting in functional disability and reduced quality of life. Management of the disease includes therapeutic intervention, supportive therapies, and regular monitoring ...

fatigue is recognized as one of the most disabling and frequent symptoms of multiple sclerosis (ms). amantadine appears to have some proven ability to alleviate the fatigue in ms. the aim of this study was to assess the efficacy of co-administration of amantadine and aspirin for the treatment of fatigue in multiple sclerosis. forty-five ambulatory patients aged 20–50 years with a diagnosis of m...

Introduction Performance-based building codes have been under development in various countries for the last two decades. The United States has been one of the last major countries to start such an effort, but such development is well underway here, with the notable landmark being the issuance of the first draft of the IBC (International Building Code) performance-track code in 1998 [1]. Simply ...

Paralyzed muscle fatigues more quickly than intact muscle. The reason for this difference is currently unknown. This work will bridge this gap in knowledge by evaluating the predictive abilities of higher-resolution closed-form mathematical models of muscle force and fatigue. Knowledge garnered from this effort will suggest possible mechanisms for the differences in fatiguability of muscle in d...

Puberty is characterized by a large number of physiological modifications that translate into increased neuromuscular fatigue during high-intensity exercise in adolescents compared to prepubertal children. This greater neuromuscular fatigue in adolescents could be attributed to peripheral (i.e., muscular) and central (i.e., nervous) factors that change through puberty. Among the peripheral chan...