Granuloma multiforme (GM) is a reactive skin disorder of unknown etiology, characterized clinically by confluent annular lesions and histologically by focal necrobiosis and histiocytic granulomas. GM is significant because of its clinical resemblance to tuberculoid leprosy, with which it can be confused. Here, we report a case of granuloma multiforme from India in a 70-year-old male farmer, wit...

Granulomas are focal infiltrates consisting mainly of macrophages or macrophage-derived cells (epithelioid, giant cells), chiefly in the case impossibility slow degradation specific antigens. The variability manifestations complicates clinical and pathological diagnosis granulomatous skin diseases due to individual patient reactivity specifics often unidentified triggering factors. mini-review ...

Background: Granuloma annulare is a difficult disease to treat and can lead anxiety frustration for both patients providers. The pathogenesis of granuloma unknown, resulting in few thoroughly studied or consistently effective treatments.
 Objective: 1) To discuss whether treatment with apremilast could improvement resolution generalized annulare. 2) explore the possible mechanism treating ...

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease of unclear pathogenesis which belongs to the group of disorders in the skin and elastic fibers with similar clinical features of granuloma annulare (GA). This case report is intended to describe a rare hybrid pattern in histopathology demonstrating coexistence of AEGCG and GA. An endocrine disease, such as dia...

Perforating granuloma annulare (GA) is a rare subset of GA with an unknown etiology and chronic course. Herein, we report the case of 72 year-old women with a 3-month history of a post-traumatic, persistent, erythematous and exudative plaque located on her left leg. Differential diagnosis included mycobacterial infection, subcutaneous mycosis, perforating dermatoses, pyoderma and squamous cell ...