HYPERACUTE rejection (HAR) of the kidney was first recognized 20 years ago in cases of donor-recipient incompatibility for the major blood group and tissue antigen systems. I•3 Recently, three patients at the University of Pittsburgh developed immediate graft dysfunction after receiving a kidney from an ABO-compatible cadaveric donor with a negative warm lymphocytotoxic crossmatch. None of the ...

Hematopoietic stem cell transplantation (HSCT) has been one of the revolutionary discoveries in the world of science leading to cure of many of the hematological malignancies and for several nonmalignant conditions. It involves harvesting of stem cells from either the bone marrow most traditionally, peripheral blood or umbilical cord and then transplanting them into a recipient [1-3]. This coul...

Cholestasis is a common sequela of liver transplantation. Although the majority of cases remain subclinical, severe cholestasis may be associated with irreversible liver damage, requiring retransplantation. Therefore, it is essential that clinicians be able to identify and treat the syndromes associated with cholestasis. In this review, we consider causes of intrahepatic cholestasis. These may ...

By using an indirect immunofluorescence technique, the presence of host cell derived H-2K, H-2D, and Ia alloantigens on donor cells recovered from recipient spleens after a graft-versus-host response (GVHR) was demonstrated. Mapping studies indicated that only host K, D, and I-A region gene products could be identified on the donor cells. Host I-E/C- and I-J-subregion products were not absorbed...

In some families of flowering plants, a single self-incompatibility (S) locus prevents the fertilization of flowers by pollen from the same plant. Self-incompatibility of this type involves the interaction of molecules produced by the S locus in pollen with those present in the female tissues (pistil). Until recently, the pistil products of the S locus were known in only two families, the Brass...