The objective of the study was to assess the carboplatin sustained-release (CSR) as an injectable, biodegradable polymer system designed to uniformly release carboplatin over 30 days at a dose of 350 mg m-2. The study involved seven client-owned dogs with histologically or cytologically confirmed neoplasia that were treated with CSR intramuscularly. Platinum levels were measured at days 0, 7, 1...

PURPOSE To measure shear wave velocities (SWVs) by acoustic radiation force impulse (ARFI) ultrasound elastography in normal kidneys and in hydronephrotic kidneys in young children and to compare SWVs between the hydronephrosis grades. METHODS This study was approved by an institutional review board, and informed consent was obtained from the parents of all the children included. Children und...

OBJECTIVE Identify prognostic factors associated to late urinary toxicity in patients with prostate cancer submitted to radical conformal radiotherapy (3DCRT). MATERIALS AND METHODS From July 1997 to January 2002, 285 patients with localized prostate cancer were consecutively treated with 3DCRT and retrospectively analyzed. Thirty seven (13%) patients were submitted to transurethral prostate ...

In preclinical studies, the topoisomerase I inhibitor irinotecan (Camptosar, CPT-11) has demonstrated activity as a radiosensitizer, probably due to its ability to inhibit potentially lethal radiation damage repair. We conducted a phase I trial to determine the maximum-tolerated dose (MTD) and dose-limiting toxicities (DLT) of weekly irinotecan with concurrent thoracic radiation therapy for pat...

The goal of the research was to define experts opinion about adequate criteria for water polo players' actual quality evaluation and to determine experts opinion about weight coefficients (ponders) of the here defined criteria across the playing positions in the game of water polo. Based upon the expertise performed by ten water polo professionals, the relative importance coefficients with rega...

AIM To obtain the views of specialist registrars on specialty care in the community. METHOD Specialist registrars from five Deaneries in England completed an online questionnaire about their views on employment prospects, the role of specialty care in the community, and the need for additional training in this area. RESULTS One hundred and twenty seven replies were received over a four week...

Challenge and threat states predict future performance; however, no research has examined their immediate effect on motor task performance. The present study examined the effect of challenge and threat states on golf putting performance and several possible mechanisms. One hundred twenty-seven participants were assigned to a challenge or threat group and performed six putts during which emotion...