BACKGROUND In chronic heart failure (CHF), cross-talk between inflammatory activation and oxidative stress has been anticipated in skeletal muscle (SM). The role of the radical scavenger enzymes superoxide dismutase (SOD), catalase (Cat), and glutathione peroxidase (GPX), which remove oxygen radicals, has never been assessed in the SM in this context. Moreover, it remains unknown whether exerci...

Lentinula edodes (Berk) Pegler, commonly known as Shiitake mushroom has been used as medicinal food in Asian countries, especially in China and Japan and is believed to possess strong immunomodulatory property. In the present study, the methanolic extract of the fruit bodies of L. edodes was investigated for cytoprotective effect against H2O2-induced cytotoxicity in human peripheral blood monon...

In order to evaluate the anti-mutagenic effects of the potential chemoprotective compounds selenium and (S)-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-1065), CHO AA8 cells were exposed to both compounds either individually or in combination prior to irradiation. Mutation frequency following exposure to 8 Gy was evaluated by quantitation of the mutations detected at the hprt locus of th...

OBJECTIVES Glutathione (GSH) is an important element of antioxidative barrier. Its biological function consists in eliminating oxygen free radicals. It also acts as a co-substrate in numerous enzymatic reactions catalyzed by glutathione peroxidase (GPx) and glutathione S-transferase (GST). In our study we attempted to assess the effect of hexabromobenzene (HBB) and its metabolites on the level ...

Introduction: Antioxidant defense components protect insects by scavenging reactive oxygen species, leading to oxidative stress. We therefore investigated the effect of an organophosphate insecticide, dichlorvos, on superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione S-transferase (GST) and glutathione reductase (GR) as antioxidative biomarkers in silk worm, Bo...

Most human selenium containing proteins contain selenium in the form of the amino acid selenocysteine, which is encoded in the corresponding mRNA as a UGA codon. Only a few non-selenocysteine containing selenoproteins are present and the nature of the association with selenium is not well understood. This review focuses on two selenocysteine-containing proteins that are members of the glutathio...

Certain forms of dietary Se may have advantages for improving human Se status and regulating the risk for disease, such as cancers, including colorectal cancer (CRC). The present study compared the effects of a Se-enriched milk protein (dairy-Se) with a Se-rich yeast (yeast-Se) on plasma Se levels and rectal selenoprotein gene expression since we reasoned that if these genes were not regulated,...

The objective of this research was to determine the influence of dietary Se on various indicators of Se status and relative liver glutathione peroxidase 1 (GPx-1) messenger RNA (mRNA) levels in growing Holstein bull calves. Calves (n = 14, 7/diet) were started 28 d after birth on a Se-adequate (SeA) or Se-deficient diet (SeD) and maintained on the diet until 180 d of age. Blood samples were tak...

Glutathione peroxidase (GPx) is a family of antioxidant enzymes that reduce reactive oxygen species (ROS), thereby constituting a primary defence system against oxidative stress. Of the five characterised isoforms of GPx found in mammals, GPx1 is the predominant intracellular form and GPx3 is the predominant form found in the extracellular space1. Experimental studies have demonstrated that def...

Blood platelets are considered to be a peripheral marker in schizophrenia and other psychiatric disorders. Oxidative stress in schizophrenia may be responsible for changes in platelet metabolism and function; therefore, the aim of this study was to examine and compare the generation of superoxide anions and activity of an antioxidant enzyme (glutathione peroxidase [GPx]) in blood platelets in p...