The article is devoted to the study of process obtaining a new water-soluble complex imino derivative gossypol, its physicochemical and structural parameters. N-polyvinylpyrrolidone (N-PVP, M.m. 8000) for medical use was chosen obtain gossypol. During study, we tested methods several complexes, which are proposed in classical literature information resources. following method used complex: goss...

We synthesized and study the possible trypanocidal activity of 4-isopropyl salicylaldehyde and 4-isopropyl salicylic acid, these compounds were chemical derivatives of gossypol, a drug that inhibits the growth of T. cruzi in culture. These derivatives were tested in two T. cruzi strains with different in vitro susceptibility to benznidazole and nifurtimox, used as a reference drugs. It was foun...

In a previous study of the influence of certain dietary constituents on the response of rats to gossypol ingestion {2) ^ the authors showed that the toxicity of diets containing known amounts of gossypol was materially reduced when the diets were made basic by the addition of calcium carbonate and sodium bicarbonate. When the diets were made acidic by the addition of calcium chloride, only indi...

This study investigates the inhibitory activities of gossypol, a natural polyphenolic compound from Gossypium spp., against Helicobacter pylori (HP) clinical strains and urease enzyme that plays key role in pathogenesis HP. Gossypol was detected to exhibit bacteriostatic action all HP tested with minimum concentration (MIC) values ranging 3.51 4.14 µg/mL. The activity (HPU) efficiently impeded ...

The action of gossypol, a polyphenolic bisnaphthalene aldehyde, on a number of drug-sensitive and multidrug-resistant cell lines, in particular MCF-7 WT and MCF-7 ADR cells, was studied and compared to the effects of rhodamine 123. " P nuclear magnetic resonance spectra of cells exposed to low concentrations of gossypol exhibited decreased levels of ATP, markedly increased levels of pyridine nu...

Background: Gossypol is a polyphenol isolated from the cotton plant (Gossypium sp.). The substance, shows promise for use as a male contraceptive, is a derivative of cottonseed oil. Various species of animals have been tested and some are more sensitive than others, and in men it causes spermatogenesis arrest at relatively low doses. Materials and Methods: This routine data base study re-examin...

ABT-737 is a small molecule Bcl-2 homology (BH)-3 domain mimetic that binds to the Bcl-2 family proteins Bcl-2 and Bcl-xL and is currently under investigation in the clinic. In this study, we investigated potential mechanisms of resistance to ABT-737 in leukemia cell lines. Compared with parental cells, cells that have developed acquired resistance to ABT-737 showed increased expression of Mcl-...

Gossypol was examined in relation to its effect on certain enzymes and enzyme complexes associated with the tricarboxylic acid cycle and the electron transport system. Succinic dehydrogenase and cytochrome oxidase activity from sweet potato was completely inhibited by gossypol at 7.5 x 10(-3)m and 2.0 x 10(-3)m, respectively. Succinoxidase activity of the same preparations was fully inhibited a...

Burkitt lymphoma is a highly aggressive B-cell neoplasm. New therapeutic methods are needed to overcome the adverse effect of intensive chemotherapy regimens. Valproic acid and (-)-gossypol are two kinds of chemical compounds used as new anti-tumor drugs in recent years. To investigate the anti-tumor effect of valproic acid and (-)-gossypol, Burkitt lymphoma Namalwa cells were cultured and trea...

Mammalian seminal plasma contains many distinct components which are important for spermatozoal function and survival. Recent studies clearly indicated that gossypol has pronounced hazardous effects on seminal characteristics and seminal plasma constituents in male rabbits, which may lead to deleterious productive and reproductive performance. We examined the possible deleterious effects of two...