gonococcus subverts the immune system, and takes advantage of the immune privilege of the genital tract to foster an environment that is hospitable to this pathogen. Since infection does not elicit a protective response, a gonococcal vaccine has been sought for many years. Zhu et al. (2011) present a summary of gonococcal vaccine development efforts, including a previously unpublished study tes...

In a prospective survey of 106 male homosexuals, investigations included smears and cultures of material taken from the tonsillar areas. A diagnosis of gonococcal pharyngitis was made in six cases. This is the largest series so far reported from England. The prevalence of gonorrhoea nd less conventional sexual practices must prompt us to investigate gonococcal infection in sites remote from the...

UNLABELLED The sexually transmitted infection gonorrhea is caused exclusively by the human-specific pathogen Neisseria gonorrhoeae. Type IV pili are an essential virulence factor uniformly expressed on clinical gonococcal isolates and are required for several aspects of gonococcal pathogenesis, including adherence to host tissues, autoagglutination, twitching motility, and the uptake of DNA dur...

We evaluated the use of silver nitrate drops and tetracycline ointment for the prophylaxis of ophthalmia neonatorum in a controlled trial involving 2732 newborns in Nairobi, Kenya. The overall rates of prevalence of intrapartum maternal gonococcal and chlamydial infection were 6.4 and 8.9 percent, respectively. After prophylaxis with silver nitrate, the incidence rates of gonococcal, chlamydial...

The quest for a vaccine against Neisseria gonorrhoeae has been long, arduous, and, to date, unsuccessful. Indeed, some experts, citing the recurrent nature of gonococcal infections in some people, have believed the task to be impossible (2). However, there has been at least one human challenge study that has demonstrated protection against the homologous infecting organism after immunization wi...

Differentiation between Reiter's syndrome (RS) and gonococcal arthritis may be difficult, since both conditions are characterised by arthritis and urethritis. Holmes and coworkers156 noted that 13 out of 23 patients who later developed RS were initially thought to have gonococcal arthritis, and both diseases are by no means virtually exclusive. Patients with culture-positive gonococcal urethrit...

OBJECTIVE To study the prevalence of genital chlamydia and gonococcal infections in women at risk of acquiring sexually transmitted infections in the Kumasi metropolis, Ghana. DESIGN Structured interviews and clinical examination of participants and obtaining vaginal swabs to test for gonorrhoea and chlamydia infections. PARTICIPANTS Women aged between 18-35 years (inclusive) with a history...

1. Holmes KK, Counts GW, Beaty HN. Disseminated gonococcal infection. Ann Intern Med 1971;74:979-93. 2. Gurbani SG, Cho TC, Lee KR, Powell L. Gonococcal abscess ofthe obturator internus muscle: use of new diagnostic tools may eliminate the need for surgical intervention. Clin Infect Dis 1995;20:1384-6. 3. Fitzpatrick JE, Gramstad ND, Tyler H. Primary extragenital cutaneous gonorrhea. Cutis 1981...

Sixteen patients with aseptic arthritis developing after gonorrhoea and 14 patients with arthritis after nongonococcal urogenital infection have been analysed with respect to clinical course, roentgenological signs, and humoral as well as cellular immune responses to Neisseria gonorrhoeae antigen. Fifty-eight healthy blood donors were used as controls. The clinical pattern did not differ signif...

1. Adolescents (15–19 years of age) and young adults (20–24 years of age) account for the majority of new cases of gonorrhea reported each year. Gonococcal infections in postpubertal females are commonly asymptomatic. Complications such as pelvic inflammatory disease (PID) and disseminated gonococcal infection (DGI) occur more often in females, probably because of delays in diagnosis and treatm...