Abstract Study question What are the dynamics of toxicity from 4-hydroperoxycyclophosphamide (4-HC) on male germ cell line and prepubertal mouse testes? Summary answer Chemotherapy has dose- time- dependent harmful effects genes regulating apoptosis survival in two different models. is known already Fertility preservation strategies offered to boys during oncological treatment limited. The deve...

Abstract Study question What is the impact of treatment for Hodgkin lymphoma (HL) on clinical reproductive markers and pregnancy outcomes? Summary answer Impaired ovarian reserve in childhood HL survivors substantiate risk a reduced fertile life span. Pregnancy outcomes seem reassuring at young age. known already Childhood Lymphoma nowadays highly curable with survival rates over 90%. Chemother...

Abstract Study question Does carboplatin and paclitaxel regimen have a toxic cumulative impact on the ovarian reserve of young breast cancer patients with germline Breast Cancer (BRCA) mutation? Summary answer Based follicle classification survival through apoptosis DNA repair mechanism recruitment analyses, gonadotoxic but no effect was observed in BRCA-mutated tissue. What is known already Ov...

Abstract Study question What are the medical and ethical challenges of performing ovarian stimulation oocyte cryopreservation in adolescents what barriers to provision? Summary answer Oocyte for benign malignant indications is associated with unique challenges. known already An improvement childhood cancer survival, increased transgender care conditions such as haemoglobinopathies requiring ste...

STUDY QUESTION Do genetic variations in the testosterone pathway genes modify the effect of treatment on the levels of testosterone and LH in long-term testicular cancer (TC) survivors (TCSs)? SUMMARY ANSWER Variations in LH receptor (LHR) and in 5α-reductase II (SRD5A2) genes may modify the effect of TC treatment on testosterone levels, whereas genetic variations in the androgen receptor (AR...

STUDY QUESTION Are genetic polymorphisms, previously identified as being associated with age at menopause in the healthy population, associated with ovarian reserve and predicted age at menopause in adult long-term survivors of childhood cancer? SUMMARY ANSWER The CT genotype of rs1172822 in the BRSK1 gene is associated with lower serum anti-Müllerian hormone (AMH) levels and a younger predic...

Biomarkers have achieved broad logical and clinical attention in diverse disciplines such as screening, diagnosis, prognosis, recurrence prediction and therapeutic monitoring of diseases in modern medicine. Due to lack of direct access to the function of reproductive organs and their malfunction especially in women, most of data are received through application of sensitive and specific biomark...