In this paper, we solve the problem of learning a generalized Nash equilibrium (GNE) in merely monotone games. First, propose novel continuous semi-decentralized solution algorithm without projections that uses first-order information to compute GNE with central coordinator. As second main contribution, design gain adaptation scheme for previous order alleviate improper scaling cost functions v...

The present study investigated the voice quality associated with adductor spasmodic dysphonia by means of various acoustical measures. Energy distribution analyses and nonlinear dynamical measurements were used to depict the differences among voices associated with adductor spasmodic dysphonia (ADSD), vocal nodules (VN) and normal voices. Possible acoustical differences between voices associate...

Hereditary inclusion body myopathy type 2 (HIBM2) is a myopathy characterized by progressive muscle weakness with early adult onset. The disease is the result of a recessive mutation in the Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase gene (GNE), which results in reduced enzyme function and sialic acid levels. A majority of individuals with HIBM2 are from Iranian-Jewish or ...

We investigated an uncommon biotransformation of pyrimidine during the metabolism of GNE-892 ((R)-2-amino-1,3',3'-trimethyl-7'-(pyrimidin-5-yl)-3',4'-dihydro-2'H-spiro[imidazole-4,1'-naphthalen]-5(1H)-one), a β-secretase 1 inhibitor. Three novel metabolites, formed by conversion of pyrimidine to pyrazole, were observed in the (14)C-radiolabeled mass balance study in rats. Their structures were ...

Limb-girdle muscular dystrophies (LGMDs) are common in India. Information on LGMDs has been gradually evolving in the recent years. This information is scattered in case series and case studies. The aim of this study is to collate available Indian information on LGMDs and put it in perspective. PubMed search using keywords such as limb-girdle muscular dystrophies in India, sarcoglycanopathies, ...

Distal myopathy with rimmed vacuoles (DMRV) is an autosomal recessive or sporadic early adult-onset myopathy caused by mutations in the UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase (GNE) gene. Characteristic pathologic features of DMRV are rimmed vacuoles on muscle biopsy and tubulofilamentous inclusion in ultrastructural study. Presence of inflammation in DMRV is unusual....

Introduction Sialic acid (N-acetylneuraminic acid, NeuAc, Neu5Ac) is an essential terminal sugar on the glycan moieties of many functional and structural human glycoproteins. A key intermediate in the biochemical process to form sialic acid is the monosaccharide, ManNAc, which is formed by the bifunctional enzyme UDPN-acetylglucosamine / Nacetylmannosamine epimerase kinase (GNE). ManNAc is an i...

With the proliferation of distributed generators and energy storage systems, traditional passive consumers in power systems have been gradually evolving into so-called “prosumers,” i.e., proactive consumers, which can both produce consume power. To encourage exchange among prosumers, sharing is increasingly adopted, usually formulated as a generalized Nash game (GNG). In this paper, approach pr...

Background: The assessment of voice quality can be evaluated perceptually with standard clinical practice, also including acoustic evaluation digital recordings to validate and further interpret perceptual judgments. goal the present study was determine strongest parameters for perceived hoarseness breathiness when analyzing sustained vowel [a:] using a new tool, VOXplot software. Methods: A to...