A convenient synthesis of the tetrasaccharide repeating unit of the O-antigen of Shigella boydii type 9 has been achieved in excellent yield using a [2 + 2] block glycosylation strategy. TEMPO-mediated selective oxidation of the primary alcohol of the tetrasaccharide derivative 8 to the carboxylic group followed by deprotection of the functional groups furnished target tetrasaccharide 1 as its ...

The techniques of metagenomics have allowed researchers to access the genomic potential of uncultivated microbes, but there remain significant barriers to determination of gene function based on DNA sequence alone. Functional metagenomics, in which DNA is cloned and expressed in surrogate hosts, can overcome these barriers, and make important contributions to the discovery of novel enzymes. In ...

Glycosynthases provide a rare and practical source of catalytic synthetic utility for oligosaccharide and other glycoside synthesis. These biocatalysts, nucleophile-less mutants of retaining glycosidases, are typically exquisitely stereoselective (inverting) enzymes and some can also attach monosaccharides with good regioselectivity. Many examples now exist, but in most cases b-glycosides are s...

A new Erythrina alkaloid glycoside, named erythraline-11β-O-glucopyranoside, was isolated from the seeds of Erythrina crista-galli L., together with five known Erythrina alkaloids and an indole alkaloid. The structure of the new alkaloid glycoside was elucidated by spectroscopic methods, and all of the compounds were evaluated for their antiviral activity against tobacco mosaic virus.

Two glycosides were isolated from the n-Butanol soluble portion of the ethanolic portion of the stem and leaves part of stachytarpheta angustifolia. Their structures were elucidated as Iridoid glycoside (1) and a caffeic glycoside ester named as –β(3 1 , 4 1 dihydroxyphenyl)–ethyl-O-α-L-rhamnopyranosyl-(1-3)-β-D-(4-O-Caffeoyl) glucopyranoside (2) by spectroscopic Method.

Column chromatographic separation of a MeOH extract of the aerial parts of Saussurea triangulata led to the isolation of a new sesquiterpene glycoside 6, together with three quinic acid derivatives, two phenolics, two sesquiterpene glycosides and two flavonoids. The new compound 6 was identified as amarantholidol A glycoside by spectroscopic and chemical methods.

Anoxybacillus thermarum AF/04(T) was isolated from the Euganean hot springs in Abano Terme, Italy. The present work reports a high-quality draft genome sequence of strain AF/04(T). This work also provides useful insights into glycoside hydrolases, glycoside transferases, and sugar transporters that may be involved in cellular carbohydrate metabolism.

Two new lignan glycosides of dibenzylbutyrolactol type (haplomarin) and arylnaphthalene type (haploborin) were isolated from the aerial parts of Haplophyllumn suaveolens together with the known arylnaphthalene lignan glycoside arabelline and hydroxycoumarin glycoside xeroboside. So far arabelline is found only in H. buxbaunii. This is the first report of the isolation of xeroboside from Haploph...

An efficient selective demethylation and debenzylation method for aryl methyl/benzyl ethers using magnesium iodide under solvent-free conditions has been developed and applied to the synthesis of natural flavone and biphenyl glycosides. A variety of functional groups including glycoside were tolerated under the reaction conditions. Experimental results indicated that the removal of an O-benzyl ...

Preliminary phytochemical screening of petroleum ether and alcohol extract of Symplocos Racemosa Roxb was carried out which indicates that alcoholic extract contain carbohydrate, glycoside, saponin and terpenoid & alkaloid and ether extract indicated presence of glycoside, phytosterol and steroid. An antibacterial evaluation of the petroleum ether and ethanolic extract was carried out and it is...