Male Fischer-344 rats aged 6, 12, or 24 months were subjected to four-vessel occlusion cerebral ischemia to assess age-dependent ischemic vulnerability of cholinergic and GABAergic neurons based on choline acetyltransferase (EC 2.3.1.6) and glutamic acid decarboxylase (EC 4.1.1.15) activities. Activities of both enzymes were similar (p greater than 0.05) in 6- (n = 5) and 12- (n = 5) month-old ...

Antibodies to glutamic acid decarboxylase (GAD) have been predominantly associated with stiff-person syndrome (SPS), which is often accompanied by organ-specific autoimmune diseases, such as late-onset type 1 diabetes. Autoimmune retinal pathology in SPS has recently suggested coexist patients suffering from this disease; however, evidence reporting potential treatment options for the neurologi...

Stiff-person syndrome is a rare neurological disorder characterized by stiffness of skeletal muscles with superimposed spasms. The syndrome is a putative autoimmune disease occurring as an idiopathic or paraneoplastic condition. It is often associated with antibodies to glutamic acid decarboxylase (GAD) or, less commonly, to the 128 kD synaptic protein later amphiphysin (AMPH) and few other aut...

Glutamic acid decarboxylase (GAD) is an intracellular enzyme found in the presynaptic end of nerve terminals that functions to synthesize ​​gamma-aminobutyric (GABA) via decarboxylation. Autoantibodies GAD65 isoform have been high levels neurological disorders including stiff person syndrome (SPS), autoimmune encephalitis, and refractory epilepsy. Low anti-GAD65 also noted type 1 diabetes melli...

Citation for published version (APA): Persson, A., Becker, C., Jönsson, I., Ramelius, A., & Törn, C. (2010). Comparison of measurements of autoantibodies to glutamic acid decarboxylase and islet antigen-2 in whole blood eluates from dried blood spots using the RSR-enzyme linked immunosorbent assay kits and in-house radioimmunoassays. Experimental Diabetes Research, 2010, [173652]. DOI: 10.1155/...

Abbreviations: CAT, chloroform acetyltransferase; CDR, complementary determining region; EAE, experimental autoimmune encephalomyelitis; GAD65, glutamic acid decarboxylase 65; HEL, hen egg lysozyme; MBP, myelin basic protein; MLN, mesenteric lymph node; NOD, nonobese diabetic; PLN, pancreatic lymph node; scTCR, single-chain TCR; sIA-Ig, soluble IA-Ig; SPR, surface plasmon resonance; TCR, T cell...

In a patient with a rapidly progressive neurological condition with ataxia and cognitive complaints, Creutzfeldt-Jakob disease (CJD) is often high in the differential, particularly when there is an elevated CSF 14-3-3 protein level. We present a case of anti-glutamic acid decarboxylase antibody (anti-GAD65) positive cerebellar ataxia associated with cognitive complaints and elevated CSF 14-3-3 ...

Citation for published version (APA): Persson, A., Becker, C., Jönsson, I., Ramelius, A., & Törn, C. (2010). Comparison of measurements of autoantibodies to glutamic acid decarboxylase and islet antigen-2 in whole blood eluates from dried blood spots using the RSR-enzyme linked immunosorbent assay kits and in-house radioimmunoassays. Experimental Diabetes Research, 2010, [173652]. DOI: 10.1155/...