Abstract In recent years the prevalence of diabetes has increased globally and by 2040 number diabetic people been estimated to increase 642 million. Various classes drugs are available treat Type ll diabetes. However, these associated with certain side effects. ?-Glucosidase is an intriquing target enzyme II diabetes, ?-glucosidase inhibitors considered as first-line for patients. Fungi, in ge...

Diabetes is known as a multifactorial disease. The treatment of diabetes (Type II) is complicated due to the inherent patho-physiological factors related to this disease. One of the complications of diabetes is post-prandial hyperglycemia (PPHG). Glucosidase inhibitors, particularly α-amylase inhibitors are a class of compounds that helps in managing PPHG. Six ethno-botanically known plants hav...

Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE), derived from the marine algae, is a potential α-glucosidase inhibitor for type 2 diabetes treatment. In the present study, a synthetic route was established as a valid approach to obtain BDDE. Fluorescence spectra, circular dichroism spectra and molecular docking methods were employed to elucidate the inhibitory mechanisms of BDDE against α-glu...

Stilbene urea derivatives as a novel and competitive class of non-glycosidic α-glucosidase inhibitors are effective for the treatment of type II diabetes and obesity. The main purposes of our molecular modeling study are to explore the most suitable binding poses of stilbene derivatives with analyzing the binding affinity differences and finally to develop a pharmacophore model which would repr...

Diabetes is one of the main health issues worldwide because its lifetime duration. To overcome this problem, current study was conducted. This investigation aims to explore ?-glucosidase and ?-secretase potential extract/fractions pure isolated compounds Syzygium cumini bark. The chloroform extract bark subjected chromatographic analysis yield compound 1. structure phytochemical (1) conducted u...