Objective: Hepatic glucose release plays a potential role in hyperglycemia in type 2 diabetes (T2D) patients. The aim of this experimental study was to determine the effect of 6 weeks of high-intensity interval training (HIIT) on fasting levels of glucose and insulin as well as glucokinase (GCK) expression in liver tissue in obese T2D rats. Materials and Methods: T2D was induced by a high-fat ...

objective: ganoderma lucidum (g. lucidum) has been suggested to increase serum insulin level.this study was undertaken to investigateits direct effect on the islets of langerhans. material and methods: male albino wistar rats were anesthetized and the islets were isolated after digestion of the pancreas with collagenase. the islets were incubated for 60 min in krebs bicarbonate buffer containin...

we have studied the ulcerogenic effect of indomethacin in stretozocin. induced diabetic rats. streptozocin (65 mg kg-1) was injected intraperitoneally to male wistar rats. the blood glucose concentration was determined continuously. blood glucose level increased significantly (p<0.001) after 30 days. gastric erosions were induced by intraperitoneal injection of indomethacin (50 mg kg-1) in fast...

OBJECTIVE To quantitate the separate impact of obesity and hyperglycemia on the incretin effect (i.e., the gain in beta-cell function after oral glucose versus intravenous glucose). RESEARCH DESIGN AND METHODS Isoglycemic oral (75 g) and intravenous glucose administration was performed in 51 subjects (24 with normal glucose tolerance [NGT], 17 with impaired glucose tolerance [IGT], and 10 wit...

results coincubation of islets with vitamin d (10 nm) and 11.1 mm glucose increased islet insulin release (37.27 ± 3.75 vs. 24.64 ± 2.83 ng/islet/24 hours; p < 0.05), while vitamin d (1 and 10 nm) decreased insulin release in the presence of 16.7 mm glucose (21.14 ± 3.58 and 18.65 ± 3.84 vs. 37.71 ± 4.63 ng/ islet/24 hours; p < 0.05). islets preincubation with vitamin d (1 and 10 nm) increased ...

The comprehensive literature data and our findings about calcium-regulating hormones participant in the glucose metabolism is analyzed. It is showed calcitonin hyperglycemic effect and its mechanisms, established contra-insulin effect of calcitonin to insulin under the pre-receptor, cell level and liver. It is ascertained the impairment of glucose metabolism under calcitonin hyperglycemia, insu...

the present study was conducted to test the effect of origanum majoranum extract (ome) of leaves on alterations induced in a model of type 2 diabetic rats. adult male wistar rats were fed high fat diet for 3 weeks and injected a single dose of streptozotocin (35 mg/kg) intraperitoneally to induce type 2 diabetic rats. diabetic rats were given aqueous extract of ome in a dose of 20 mg/kg orally ...

In this study, we investigated in rats if hydroxycitric acid (HCA) reduces the postprandial glucose response by affecting gastric emptying or intestinal glucose absorption. We compared the effect of regulator HCA (310 mg/kg) and vehicle (control) on the glucose response after an intragastric or intraduodenal glucose load to investigate the role of altered gastric emptying. Steele's one-compartm...

The transport of trace (a concentration much less than Km for transport) 2-deoxyglucose (deoxyglucose) and 3-O-methylglucose (methylglucose) into rat adipocytes was measured using 1- to 2-s pulses at 37 degrees C in the absence of glucose and in the presence of glucose with and without pre-exposure to glucose. Pre-exposure of insulin-stimulated adipocytes to 10 mM glucose for 30 min resulted in...