BACKGROUND In critically ill patients with acute kidney injury, estimates of kidney function are used to modify drug dosing, adjust nutritional therapy and provide dialytic support. However, estimating glomerular filtration rate is challenging due to fluctuations in kidney function, creatinine production and fluid balance. We hypothesized that commonly used glomerular filtration rate prediction...

http://bmj.com/cgi/content/full/333/7571/733 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/333/7571/733/DC1 "References" References http://bmj.com/cgi/content/full/333/7571/733#otherarticles 6 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/333/7571/733#BIBL This article cites 25 articl...

The uniqueness of carboplatin as a chemotherapy drug is in the fact that the systemic drug exposure produced by any dose in a patient can be reasonably estimated on the basis of his or her renal function. Calvert’s formula (1) of delivering a calculated dose in terms of target carboplatin area under the time– concentration curve (AUC) and a measured or estimated glomerular filtration rate (GFR)...

We aimed at reviewing age-related changes in kidney structure and function, methods for estimating kidney function, and impact of reduced kidney function on geriatric outcomes, as well as the reliability and applicability of equations for estimating glomerular filtration rate (eGFR) in older patients. CKD is associated with different comorbidities and adverse outcomes such as disability and pre...

Resistin, Glomerular Filtration Rate, and Insulin Resistance To the Editor: The recent article by Ellington et al1 showed a significant inverse relationship between circulating resistin levels and estimated glomerular filtration rate (eGFR) in hypertensive adults without cardiovascular disease. This association was independent of markers for insulin resistance and inflammation, suggesting that ...

Free-flow and stop-flow intratubular pressures were measured in rats with an improved Gertz technique using Landis micropipets or a Kulite microtransducer. In hydropenia, average single nephron glomerular filtration rate was 29.3 nl/min, glomerular hydrostatic pressure (stop-flow pressure + plasma colloid osmotic pressure) was 70 cm H(2)O and mean glomerular effective filtration pressure was 12...

A technique for measuring glomerular filtration rate (by six-sample plasma clearance) and extracellular fluid volume is described. The results obtained for glomerular filtration rat per extracellular fluid volume with a three blood sample technique are also presented. Concurrently with the blood sample techniques measuring plasma clearance, glomerular filtration rate per extracellular fluid vol...

Preventing coronary heart disease: high baseline risk strategy and cost effectiveness of guidelines' BMJ, vol 332, no. 7544, pp. 793. General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requir...