Chronic diseases such as diabetes mellitus and systemic hypertension have high prevalence all over the world. In majority of cases, patients having diabetes mellitus are also suffering from systemic hypertension and vice versa. Aims: The purpose of the study is to prepare a combination dosage form which can be used to treat both the diseases concomitantly, reducing pill burden and increasing pa...

An isocratic, high-performance liquid chromatography (HPLC) quantitation method was developed for the quantitative determination of metformin, glibenclamide, gliclazide, glimepiride in some antidiabetic biologically active additives. A Nucleosil C 18 , 5 μm, 4.6 mm × 150 mm, column with mobile phase containing buffer (10 Na 2 HPO 4 10 sodium dodecyl sulfate): acetonitrile = 68 : 32 (V/V), pH 7....

Experimental data suggest that vascular ATP-sensitive potassium (K(ATP)) channels may be an important determinant of functional hyperaemia, but the contribution of K(ATP) channels to exercise-induced hyperaemia in humans is unknown. Forearm blood flow was assessed in 39 healthy subjects (23 males/16 females; age 22+/-4 years) using the technique of venous occlusion plethysmography. Resting fore...

Type 2 diabetes is a chronic, degenerative disease, which requires management of the symptoms via lifestyle modification and anti-diabetic pharmacotherapies. If glycaemic targets are not maintained, patients can often require the addition of a second drug to help achieve glycaemic control. Polypharmacy represents a substantial problem in some patient groups, reducing adherence and potentially i...

Plasma cell antigen (PC-1) is an inhibitor of insulin receptor tyrosine kinase, which plays an important role in insulin resistance pathogenesis in type 2 diabetes mellitus, obesity and some other insulin resistant states. In a recent study we have demonstrated an increased lymphocyte PC-1 activity in patients with type 2 diabetes and its reversal by 3-month metformin treatment, corresponding t...

In the article by Pantalone et al. (1), the authors did not identify an increased total mortality risk among individual sulfonylureas (SUs)—glibenclamide versus glimepiride or glipizide—but did suggest that glimepiride may be the preferred SU in patients with history of coronary artery disease (CAD). The authors found that in a retrospective cohort of patients with CAD, the hazard ratio (HR) fo...

In the study, self emulsifying drug delivery system (SEDDS) of gliclazide, a poorly soluble drug, was developed and evaluated by in-vitro, ex-vivo and in-vivo techniques. Oil and surfactant were screened out according to their solubilizing capacity. Among the tested components Transcutol HP and Tween-80 showed good solubilizing capacity. These two components were used in different ratios to pre...

We investigated the association between the current use of individual sulphonylureas and the risk of a first-ever acute myocardial infarction (AMI) and all-cause mortality, in a population-based cohort study, using primary care data from the Clinical Practice Research Datalink database (2004-2012). New users (N = 121 869), aged ≥18 years, with at least one prescription for a non-insulin antidia...

OLETF (Otsuka Long-Evans Tokushima Fatty) rats are characterized by obesity-related insulin resistance, which is a phenotype of type 2 diabetes. Sulfonylurea drugs or benzoic acid derivatives as inhibitors of the ATP-sensitive potassium (K(ATP)) channel are commercially available to treat diabetes. The present study compared sulfonylurea drugs (glimepiride and gliclazide) with one of benzoic ac...