The aim of this study was to analyse the relationship between the expression of the bcl-2 proto-oncogene and the histological grading of prostate cancer according to the Gleason score. To study the prognostic significance of Bcl-2 over expression in prostate cancer, 36 consecutive radical prostatectomy specimens were examined by immunohistochemistry. Bcl-2 was associated with malignant phenotyp...

Our aim was to study the level of interobserverconcordance in the Gleason scores of prostate needlebiopsy specimens reported at 1 institution. Aretrospective review of all prostate needle biopsyspecimens in which a diagnosis of adenocarcinoma wasmade during the year 2000 was conducted. Parametersevaluated included the Gleason score, Gleason gradesidentified, the perc...

Background To investigate prognostic difference between Gleason Score (GS) 8 and 9-10, as the 2014 International Society of Urological Pathology Gleason Grading Systems proposed, in patients with prostate cancer (PCa) with bone metastasis. Materials and methods We retrospectively reviewed data on 106 patients with GS 8-10 between 2006 and 2016. All patients received androgen deprivation thera...

Histopathological assessments, including surgical resection and core needle biopsy, are the standard procedures in the diagnosis of the prostate cancer. Current interpretation of the histopathology images includes the determination of the tumor area, Gleason grading, and identification of certain prognosis-critical features. Such a process is not only tedious, but also prune to intra/inter-obse...

Prior studies of radical prostatectomies have reported a small percentage of men with biochemical progression after radical prostatectomy showing organ-confined, Gleason Score 6. One might predict that this should virtually never occur. We identified 2551 (1983-2005) radical prostatectomies coded by the urologists at our institution as pathologically organ-confined, Gleason score 6 cancer with ...

We present an approach for automatic diagnosis of tissue biopsies. Our methodology consists of a quantitative phase imaging tissue scanner and machine learning algorithms to process these data. We illustrate the performance by automatic Gleason grading of prostate specimens. The imaging system operates on the principle of interferometry and, as a result, reports on the nanoscale architecture of...

CONTEXT Prostatic adenocarcinoma growing within acinar-ductal spaces (intraductal carcinoma) in contrast to high-grade prostatic intraepithelial neoplasia (HG-PIN) impacts negatively on patient outcome. There is currently no generally accepted definition of this lesion nor is it classified in the current prostate cancer grading system (Gleason). OBJECTIVE To define intraductal carcinoma of th...

One of the well-known and accepted methods of prostatic adenocarcinoma grading is Gleason system. The authors made a retrospective analysis of 221 prostatic adenocarcinomas divided into three groups (transvesical prostatectomies, transurethral resections and needle biopsies) following the type of surgical procedure used for drawing the tissue. Gleason scores and comparison between odd and even ...

Gleason score has long been considered the most powerful tissue-based predictor of outcome for prostate cancer. One of the strengths of this system is that it factors in the multiple grades that are often present in a single tumor. However, there is growing awareness of the limitations of Gleason grading. Specifically, few of the original Gleason criteria are currently used and cancers tend to ...

The Gleason score is one of a number of factors used in staging patients diagnosed with prostate cancer and in determining the treatment path such patients will ultimately follow. However, discrepancies in the Gleason scores obtained through biopsy compared with the final pathological staging of specimens following radical prostatectomy are not uncommon. Incorrect Gleason scoring can potentiall...