Traumatic brain injury(TBI) occurs when an external force traumatically injures the brain. TBI is a leading cause of death and disability. A complex pathophysiological cascade of cellular events is involved in it. Experimental models have shown that TBI results in a significant increase in glucose utilization following injury. Hyperglycemia aggravates underlying brain damage by causing free rad...

pharmacokinetic/pharmacodynamic (pk/pd) relationships describe the quantitative relationships between the drug-induced effects and the concurrent corresponding drug concentrations in an individual. since a long time, rough qualitative relationships have been described between neurological presentation and plasma ethanol concentration in acute ethanol ingestion. however, to date, precise quantit...

Objective: The goal of this study were to identify the factors that may predict the outcome of subarachnoid hemorrhage (tSAH) patients, and to assist in the management of their treatment. Methods: We retrospectively studied 90 patients admitted to our hospital in the two-year period from January 1, 2003, to December 31, 2004, with an initial computed tomographic (CT) diagnosis of tSAH. Follow-u...

BACKGROUND Prognostication for survivors of cardiac arrest is a frequent challenge to neurologists. Our aim was to determine whether the FOUR (Full Outline of UnResponsiveness) score is an accurate predictor of outcome in patients after cardiac arrest and to compare its performance to the Glasgow Coma Scale (GCS). METHODS We prospectively identified patients surviving cardiac arrest from June...

normal 0 false false false en-us x-none fa microsoftinternetexplorer4 background : erythropoietin (epo) as a major stimulator of red blood cell (rbc) production play a key role on brain protection and have a caring effect on neurons from hypoxic or traumatic injury. the objective of this trial was to study the safety and efficacy of recombinant human epo (rhepo) on level of consciousness and ot...

OBJECTIVE Spontaneous cerebellar hemorrhage (SCH) is less common than supratentorial intracerebral hemorrhage. This study investigated the treatment of SCH and the relation between its clinical and radiological manifestation and outcome. MATERIALS AND METHODS We presented a SCH management protocol in our institute and analyzed the clinical and radiological findings in 41 SCH patients. The out...

Patients with isolated severe head injury with diffuse axonal injury and without any surgical lesion may be treated safely without cerebral resuscitation and intracranial pressure (ICP) monitoring. Seventy two patients were divided into three groups of patients receiving treatment based on ICP-CPP-targeted, or conservative methods either with or without ventilation support. The characteristics ...

A prospective study was done during a six-month period on 104 consecutive patients who were seen at the Accident and Emergency (A&E) Department of the UHWI and referred for CT scans of the head within 24 hours of sustaining head injuries. There were 74 (71.1%) males and 30 (28.8%) females. The mean age for females was 40.6 years and 32.4 years for males. Patients were clinically assessed for th...

objectives we aim to evaluate the role of glibenclamide on the short-term outcome of patients with dai due to moderate to severe tbi. patients and methods in this controlled randomized clinical trial, 40 patients with moderate to severe tbi were assigned to glibenclamide (n = 20) and control (n = 20) groups. six hours after admission the intervention group received 1.25 mg glibenclamide every 1...