OBJECTIVE To compare performance after cochlear implantation in children with mutations in connexin (Cx) 26 (GJB2) or Cx30 (GJB6) and children with deafness of unknown etiology. DESIGN Genetic analysis and speech perception evaluation was performed in the children with and without Cx mutations who had undergone cochlear implantation. Speech perception performance was retrospectively analyzed ...

BACKGROUND Gap junctions composed of connexins (Cx) are functional in cell defense by propagation of toxic/death molecules to neighboring cells. Hippocampus, one of the brain regions with particular vulnerability to damage, has a wide network of gap junctions. Functional response of astrocytic Cx30 and neuronal Cx32 to hippocampal damage is unknown. METHODS We infused lipopolysaccharide (LPS)...

Introduction: The source and duration of the heating event responsible for eucrite metamorphism is not well constrained. Three hypotheses have been proposed for the source of heat: Impact, conduction from the mantle, and rapid production of successive flows [1]. Textural and chemical relationships of noncumulate eucrites are investigated to constrain the thermal and temporal conditions responsi...

Genetic diseases demonstrate that the normal function of CNS myelin depends on connexin32 (Cx32) and Cx47, gap junction (GJ) proteins expressed by oligodendrocytes. GJs couple oligodendrocytes and astrocytes (O/A channels) as well as astrocytes themselves (A/A channels). Because astrocytes express different connexins (Cx30 and Cx43), O/A channels must be heterotypic, whereas A/A channels may be...

Much of 21st century plasma physics will involve work to produce, understand, control, and exploit very nontraditional plasmas. High-energy-density HED plasmas are often examples, variously involving strong Coulomb interactions and 1 particles per Debye sphere, dominant radiation effects, and strongly relativistic or strongly quantum-mechanical behavior. Indeed, these and other modern plasma sy...

Inherited Palmoplantar Keratodermas are rare disorders of genodermatosis that are conventionally regarded as autosomal dominant in inheritance with extensive clinical and genetic heterogeneity. This is the first report of a unique autosomal recessive Inherited Palmoplantar keratoderma -sensorineural hearing loss syndrome which has not been reported before in 3 siblings of a large consanguineous...