Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract and arises from the interstitial cells of Cajal. It is characterized by expression of the receptor tyrosine kinase CD117 (KIT). In 70-80% of GIST cases, oncogenic mutations in KIT are present, leading to constitutive activation of the receptor, which drives the proliferation of these tumors. Treatment...

Colorectal mesenchymal tumors are rare. Therefore, distinguishing between gastrointestinal stromal (GIST) and smooth muscle tumors is important. This study aimed to delineate the immunophenotype and prognostic factors of 75 colorectal mesenchymal tumors. Fifty-three GIST and 22 smooth muscle tumor specimens were included from 1986 to 2007. Forty of 53 GIST were initially diagnosed as smooth mus...

Retroperitoneal E-GIST is a very rare tumor and a total of 58 cases have been reported in the literature (2). The distinction of E-GIST from gastrointestinal stromal tumors (GIST) is made by proving the origin outside the alimentary system and ruling out a concurrent neoplasm in the gastrointestinal tract. In this letter, we aimed to report a very rare form of E-GIST arising from the retroperit...

We report two cases of a Gastrointestinal Stromal Tumor (GIST) synchronous and metachronous, respectively, with pancreatic adenocarcinoma. To our knowledge, this is the first report of a GIST involved 3 years after a ductal pancreatic adenocarcinoma. Data from the literature and our cases seem to suggest that incidental GIST may occur synchronously and metachronously with other cancers more fre...

The idea that the gist of a visual scene is perceived before attention is focused on the details of a particular object is becoming increasingly popular. In the auditory system, on the other hand, it is typically assumed that the sensory signal is first broken down into streams and then attention is applied to select one of the streams. We consider evidence for an alternative: that, in close an...

Gastrointestinal stromal tumours (GIST) are thought to derive from the interstitial cells of Cajal (ICC) or an ICC precursor. Oncogenic mutations of the receptor tyrosine kinase KIT are present in most GIST. KIT K642E was originally identified in sporadic GIST and later found in the germ line of a familial GIST cohort. A mouse model harbouring a germline Kit K641E mutant was created to model fa...

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. Except for surgical resection, no effective treatment strategies have been established. Photodynamic therapy (PDT) consists of intravenous administration of a photosensitizer, activated by a specific wavelength of light, which produces reactive oxygen species that directly kill tumor cel...

Background: Gastrointestinal stromal tumours (GISTs) are uncommon sarcomas. Surgery and target therapy the primary modalities in treating GIST. KIT expression is cornerstone diagnosis of GIST, yet its absent a small percent GISTs. The precise behaviour treatment effects, particularly therapy, prognosis these cases unclear; hence this study was designed to investigate them.

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumors of the gastrointestinal tract. In this report, we present a case of GIST patient who had been treated with imatinib, but developed leiomyoma and intra-abdominal fibromatosis (IAF) at the site of GIST resection beds mimicking recurrent GIST. To our knowledge, no patient with the 3 gastrointestinal tumor types we encounte...