A giant cell tumor (GCT) is an osteolytic tumor occurring in young adults at the epiphysis or end of the long bone. This occurs after the epiphyseal plate has ossified and longitudinal bone growth is completed. Giant cell tumor is one of the most obscure and intensively examined tumours of bone. Its histogenesis is uncertain, the histology does not predict the clinical outcome and there are sti...

BACKGROUND Typical aneurysmal bone cysts (ABCs) are osteolytic, multicystic lesions with parietal sclerosis and blood-filled cysts. In rare instances, the cystic components may be completely absent. Such solid variants in ABC (s-ABC) exhibit a solid architecture; making the clinical, radiological, and histological differentiation from other solid bone tumors like osteosarcoma (especially giant ...

Giant cell tumor of soft parts (GCtSP) is an extremely rare soft tissue tumor that resembles its counterpart in bone. It is considered a soft tissue counterpart of giant cell tumor of the bone (1-3). The tumor is composed of an admixture of osteoclast-like multinucleated giant cells and mononuclear stromal cells (3,4). The lesion was first described in 1972 by Salm and Sissons and Guccion and e...

Giant cell tumor is a benign locally aggressive tumor. The standard treatment is en bloc resection followed by major reconstructive surgery, or extended curettage conjunction with bone grafting or the use of bone cement implantations. Surgical treatment of giant cell tumor at the sacrum is associated with high morbidity, and local recurrence. The authors present a case of giant cell tumor at th...

ependymomas accounts for about 2%–6% of cns and 60%–70% of spinal cord tumors. several histological patterns of these neoplasms are well known, but little attention has been devoted to a variant composed of giant cells. in spite of apparently “worrisome” histology, giant cell ependymoma seems to be a neoplasm with a relatively good prognosis. this report presents a case of giant cell ependymoma...

Giant cell tumor of bone is a locally aggressive tumor with a high local recurrence rate. Several adjuvant therapies have been employed to reduce the recurrence rate, but their effectiveness remains controversial. The authors attempted local administration of zoledronic acid, a nitrogen-containing bisphosphonate that strongly inhibits bone resorption, as an adjuvant treatment for histologically...

The authors report on a rare case of metachronous, multicentric giant cell tumor of bone in a young woman. The first lesion occurred in the right fibular head at 26 years of age, which was surgically treated. Twenty-seven months later, the second lesion developed in the right rib, and the patient underwent an excision of the tumor. Histologically, both tumors showed typical appearance of conven...

Giant-cell tumor of the bone is a benign tumor, but with high local aggressiveness, even with risk of distant metastasis. From an epidemiological standpoint, giant-cell tumor of the bone accounts for 4-5% of primary bone tumors and ~20% of benign bone tumors; commonly affects adults between 20-40 years, slightly more common in females. We present the case of a 57-year-old woman, without signifi...

Primary neoplasms of the patella account for less than 1% of all primary bone tumors of the lower extremity, the most frequent of them being the giant cell tumor of bone, the chondroblastoma, and the aneurysmal bone cyst. Herein, we report the case of a 29-year-old woman with an active giant cell tumor of the patella (GCTP) with its clinical and radiological features and a brief review of the l...