INTRODUCTION Traditionally, insulin has been the gold standard in the management of Type 2 diabetes in pregnancy and gestational diabetes. However, insulin therapy can be inconvenient because of the needs for multiple injections, its associated cost, pain at the injection site, need for refrigeration, and skillful handling of the syringes. This has led to the exploration of oral hypoglycemic ag...

PURPOSE Various studies in placental tissue suggest that diabetes mellitus alters the expression of glucose transporter (GLUT) proteins, with insulin therapy being a possible modulatory factor. The aim of the present study was quantitative evaluation of the expression of glucose transporters (GLUT-1, GLUT-4, GLUT-9) in the placenta of women in both, uncomplicated and diabetic pregnancy. Additio...

The present article consists of the basic knowledge about diabetes with its classification as Type 1, 2, gestational well other types mellitus (DM). Diabetes is a long-term metabolic disorder defined by increased blood glucose levels. Insulin secretion and action are defective in diabetic patients. leads to irreversible damage failure many organs because chronic hyperglycemia. They have complex...

BACKGROUND Offspring born following maternal gestational diabetes are at risk of excessive childhood weight gain and Type 2 diabetes in childhood, which in turn is associated with an increased rate of hypertension. We aimed to determine the systolic and diastolic blood pressure at two years of age in a cohort of children exposed to gestational diabetes mellitus using data from the MiG trial of ...

During the twentieth century, Norbert Freinkel studied hormones [2] and diabetes in the United States. Freinkel conducted many experiments that enabled him to determine the factors that influence hormones [2] of the thyroid gland and how those hormones [2] affect surrounding tissues. Furthermore, Freinkel studied gestational diabetes, which is diabetes that occurs for the first time during a wo...

OBJECTIVE To compare the use of metformin with that of insulin for the treatment of gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) unresponsive to diet therapy. MATERIALS AND METHODS In this prospective observational study, maternal glycemic control and perinatal outcome in diabetic pregnancies were compared between 2 obstetric units, one using insulin therapy and the...

The aim of this study was to evaluate the effectiveness of metformin versus insulin in the glycemic control and to investigate the maternal and neonatal outcomes in in women with gestational diabetes mellitus. Pregnant women with gestational diabetes were randomized to either receive metformin (n=70) or insulin (n=70). Inclusion criteria were singleton pregnancy, following healthy diet and perf...

abstract objective: gestational diabetes mellitus (gdm) is characterized by glucose intolerance during pregnancy. incidence of gestational diabetes can increase by several factors such as obesity, aging, diet and genetic factors. this study aimed to assess the role of nutrition, biochemical and demographic factors in development of gdm in pregnant women. materials and methods: in this prospecti...