recurrent pregnancy loss (rpl) is a multifactorial disorder that remains idiopathic in 50% of the cases. the aim of this study was to investigate the association between mthfd1 as well as enos polymorphisms with idiopathic rpl. in a case-control study, 100 women with idiopathic recurrent pregnancy loss (prl) and 50 controls referred to noor laboratory, khoozestan, iran, were evaluated. genotypi...

OBJECTIVE To determine the frequency of various genotypes of Hepatitis C virus in District Buner, Swat. METHODS This Descriptive case series study was conducted at District Headquarter Hospital Daggar, and Bilal Medical Trust, Pir Baba, Swat, Pakistan from January 2007 to June 2008. A total of 400 patients, 154 Male and 246 Female aged 16-65 years (Mean age 31 +/- 13 years) without clinical a...

conclusions our findings indicate that heterogeneity at +2109 locus of ifn-γ gene but not at +874 locus could interfere with successful therapy in patients infected with hcv genotype 1. results of 158 patients, 110 (69.5%) subjects achieved svr and 48 (30.5%) subjects did not respond to therapy. the frequency of aa genotype (p = 0.001; or: 11.2; ci: 2.26-63.21) and a allele (p = 0.01; or: 3.23;...

Objective(s):Cytochrome P-450 1A1 is an important enzyme in the first phase of the metabolism of some carcinogens such as polycyclic aromatic hydrocarbons (PAHs), as well as estrogen. The present study evaluates the existence of CYP1A1 polymorphism in a number of breast cancer samples. Materials and Methods: One hundred breast cancer patients and the same number of healthy controls were analyz...

Schizophrenia is a complex disorder with a polygenic inheritance. Catechol-O-methyltransferase (COMT) plays a significant role in the regulation of dopaminergic systems. A polymorphism at COMT Val108/158Met has been identified in association with schizophrenia. We examined the allele and genotype association of the COMT Val108/158Met polymorphism of 297 unrelated schizophrenic patients who stri...

BACKGROUND LFA-1/JAM-A interaction plays a significant role in early steps of leukocyte transendothelial migration (diapedesis) which takes part in atherosclerosis pathogenesis. In this population-based case-control study, the frequencies of JAM-A rs790056 and LFA-1 rs8058823 gene polymorphisms in patients with coronary heart disease (CHD) and healthy subjects were investigated and the correlat...

Background: CYP2D6 is a member of cytochrome P450 enzymes family which is involved in detoxification of a wide range of xenobiotics and drugs. Several genetic polymorphisms had been shown to affect its activity which may results in increased susceptibility to malignant disorders. Aim: to detect if there is specific cytochrome CYP2D6*4 genotype associated with hepatocellular carcinoma or hepatic...

background: sarcoidosis is a multisystem inflammatory disease of unknown origin with characterization of small granulomas. angiotensin-converting enzyme (ace) is a pathophysiologic marker of sarcoidosis. we present the ace insertion/deletion (i/d) polymorphism in correlation with serum ace level in iranian patients with sarcoidosis. methods: from jan 2014 to jan 2015, 102 iranian patients who h...

Background: Hypoglycemia has been reported in LAMA2-CMD patients, but the frequency, risk factors, and correlation to genotype/phenotype have not systematically assessed date.