Infertility is a common problem that affects many couples worldwide, with an estimated 48.5 million experiencing infertility. The causes of infertility are diverse and complex, combination genetic, environmental, lifestyle factors contributing to the problem. While reproductive medicine has advanced significantly in recent years, diagnosis treatment remains challenge, particularly cases where c...

about 15% of couples have infertility problems, half of which are related to male factors. cytogenetic and genetic disorders account for about 10% of the male infertility problems. the aim of this study was to determine the frequency and types of both cytogenetic abnormalities and azf microdeletions of y chromosome in idiopathic azoospermic and oligospermic infertile men in west of iran. in thi...

One couple out of seven will have a decrease in fertility. In 40% of cases, the men will be responsible for this decrease; in 40% of cases, the women will be responsible and in the 20% left, it will be a combination of causes involving both partners. This paper will address the genetic causes of infertility including lesion at the chromosomal or gene level with the investigation of these causes.

Background Infertility affects about 15% of couples who wish to have children and half of these cases are associated with male factors. Genetic causes of azoospermia include chromosomal abnormalities, Y chromosome microdeletions, and specific mutations/deletions of several Y chromosome genes. Many researchers have analyzed genes in the AZF region on the Y chromosome; however, in 2003 the SYCP3 ...

Natural levels of infertility in many taxa are often remarkably high, amounting to a considerable fitness cost which one expects to be minimized by natural selection. Several mechanisms have been proposed as potential causes of infertility, including inbreeding depression, genetic incompatibilities and selfish genetic elements. Infertility may also be an inherent result of conflict over fertili...

Background: Subclinical hypothyroidism (SCH) remains largely unnoticed as a major cause of infertility due toasymptomatic. Polymorphisms of phosphodiesterase 8B gene (PDE8B) have been linked with various diseases,including female infertility. Hence, we aimed to study prevalence of SCH, in infertile females, explore associationof PDE8B rs4704397 A/G and rs6885099 G/A polymorphi...

Today, approximately 15% of couples have reduced fertility. In most cases the reason is male infertility, usually of genetic origin. Thus, in the context of research in genes involved in reproduction and sex determination, genetic defects in gametogenesis are being extensively studied. The most frequent pathogenic causes of male infertility are Y chromosomal microdeletions and obstructive azoos...

Endometriosis is a pathology that commonly prevails in more than 50% of women as cause dysmenorrhea and infertility we can define it the presence endometrial glands stroma outside it, is, ectopic tissue mostly located ovaries, Douglas pouch, uterosacral ligaments other anatomical sites. Infertility associated with endometriosis multifactorial disease there no certainty about mechanisms by which...