نتایج جستجو برای: generic granisetron

تعداد نتایج: 76036  

2015
Won-Suk Lee Kwang-Beom Lee Soyi Lim Young Gin Chang

BACKGROUND Selective 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are reported to have potent antiemetic effects for postoperative nausea and vomiting (PONV). The purpose of this study was to prospectively evaluate the efficacy of palonosetron, granisetron, and ramosetron for the prevention of PONV in patients undergoing laparoscopic gynecologic surgery. METHODS In this prospective...

2012
USHA DARIA VINOD KUMAR

AIM: To compare qualitatively Metoclopramide, Ondansetron and Granisetron alone and in combination with Dexamethasone in the Prevention of Postoperative Nausea and Vomiting in Day Care Laparoscopic Gynaecological Surgery under General Anaesthesia. METHOD: 180 adult female patients of ASA Grade I and II, BMI <30, aged 18 to 55 years undergoing laparoscopic gynaecological surgery under general an...

2014
Chethan Kumar

Background: Depressive disorders are major public health concern worldwide. The currently used drugs are associated with low success rate and significant drug related adverse effects. Therefore there is a focus for the development of drugs acting on different targets. As N-methyl-D-aspertate [NMDA] receptors are involved in the pathophysiology of depression, the present study was undertaken to ...

Journal: :Anticancer research 2012
Junki Endo Hirotoshi Iihara Maya Yamada Koumei Yanase Fumihiko Kamiya Fumitaka Ito Norihiko Funaguchi Yasushi Ohno Shinya Minatoguchi Yoshinori Itoh

BACKGROUND The acute antiemetic effect was compared between oral azasetron and intravenous granisetron based on the 5-hydroxytryptamine(3) (5-HT(3)) receptor occupancy theory. PATIENTS AND METHODS Receptor occupancy was estimated from reported data on plasma concentrations and affinity constants to 5-HT(3) receptor. A randomized non-inferiority study comparing acute antiemetic effects between...

Journal: :Clinical journal of oncology nursing 2007
Mark Vrabel

Nausea and vomiting are two of the most distressing side effects of chemotherapy. Guidelines recommend the use of 5-HT3 receptor antagonists as a pharmacologic intervention for acute and delayed nausea and vomiting for moderately and highly emetogenic chemotherapy. Although newer antiemetics and 5-HT3 receptor antagonists are available, ondansetron and granisetron still are used widely. A revie...

2016
Bao-xia Fang Peng Li Xiao-ya Shi Fu-chao Chen Lin-hai Wang

The administration of drugs by patient-controlled analgesia (PCA) is routinely practiced for the management of postoperative pain. It is common for 2 or more drugs to be combined in PCA solutions. The combination of analgesics and antiemetic agents is frequently required. Unfortunately, the compatibility and stability of lornoxicam and antiemetic agents, such as droperidol, ondansetrone, granis...

Journal: :Japanese journal of clinical oncology 2005
Arkom Cheirsilpa Tanadej Sinthusake Apinya Songsakkaesorn Somchit Visawaprasit Kemachit Chulaka Nunchaporn Changkuingdee

OBJECTIVE A clinical study of ramosetron was carried out to evaluate its efficacy in preventing both acute and delayed emesis in cisplatin-based chemotherapy by using a double-blind method with granisetron as the comparative drug. METHODS Cisplatin at a dose of > or =70 mg/m(2) was administered as a single intravenous (i.v.) infusion over 4 h. Patients were randomly assigned to receive either...

2013
Divya Kesters Andrew J Thompson Marijke Brams René van Elk Radovan Spurny Matthis Geitmann Jose M Villalgordo Albert Guskov U Helena Danielson Sarah C R Lummis August B Smit Chris Ulens

The 5-HT(3) receptor is a pentameric serotonin-gated ion channel, which mediates rapid excitatory neurotransmission and is the target of a therapeutically important class of anti-emetic drugs, such as granisetron. We report crystal structures of a binding protein engineered to recognize the agonist serotonin and the antagonist granisetron with affinities comparable to the 5-HT(3) receptor. In t...

2011
Smita Shenoy Lalit Mohan Saravanan Shiva Kumar Anand Ramani

Objective: The study was undertaken to compare the effect of ondansetron, granisetron and alprazolam on anxiety in rats. Materials and Methods: Elevated plus maze and Open field test were used to compare the effect of drugs on anxiety in rats. Six groups of rats were treated with 2% gum acacia orally, alprazolam 0.08mg/kg body weight of the rat orally, ondansetron (0.01mg/kg, 1mg/kg intraperito...

2013
H. Saito H. Yoshizawa K. Yoshimori N. Katakami N. Katsumata M. Kawahara K. Eguchi

BACKGROUND We evaluated the efficacy and safety of single-dose fosaprepitant in combination with intravenous granisetron and dexamethasone. PATIENTS AND METHODS Patients receiving chemotherapy including cisplatin (≥70 mg/m(2)) were eligible. A total of 347 patients (21% had received cisplatin with vomiting) were enrolled in this trial to receive the fosaprepitant regimen (fosaprepitant 150 mg...

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