Alzheimer's disease is characterized by neuronal loss and cerebral accumulation of amyloid-β protein (Aβ) and lowering the generation of Aβ is a pivotal approach in the strategy of Alzheimer's disease treatment. Midlife hypertension is a major risk factor for the future onset of sporadic Alzheimer's disease and the use of some antihypertensive drugs may decrease the incidence of Alzheimer's dis...

Oral combined hormone replacement therapy (HRT) with oestradiol and norethisterone increases plasma levels of prothrombin fragment 1+2 (F1+2), indicating an increase in thrombin generation, but the mechanisms underlying this increase are uncertain. The aim of this randomized, placebo-controlled study was to determine whether an increase in factor VII, a factor that combines with tissue factor t...

the mode of agronomic traits inheritance was investigated in safflower (carthamus tinctorius l.) in drought stress as a new report. five generation including p1, p2, f1, f2 and f3 that derived from the cross of il.111 (drought sensitive) ×mex.22-191 (drought tolerance) were used in a randomized complete block design with two replications. generation mean analysis was used to estimate genetic pa...

purpose : to investigate the effects of mtp-131 on trabeculum cells cultured under hydrostatic pressure methods : glaucomatous human trabecular meshwork (gtm3) cells were divided into three groups: the mtp-131 group, the hydrostatic group, and the normal group. the mtp-131 group was pretreated with 1 µm mtp-131, and the cells were then cultured under 80 mmhg pressure for 24 hours. the normal gr...

this is a report on the study of high melt flow, highly isotactic polypropylene homopolymer synthesized in liquid monomer using a fifth generation ziegler-natta catalytic system. at highest catalyst productivity, the response of thecatalyst to hydrogen as chain transfer is studied. melt flow rate is controlled by hydrogen as chain transfer from 0.4 to 300 g/10min with changing the amount of hyd...

the safety of hydrogen generation facilities is the main concern in their process operation. this study was conducted to identify the hazards and evaluate the risks of a hydrogen generation plant. for this purpose, prha (process hazard analysis) was applied for hazard identification while lopa (layer of protection analysis) was used for risk assessment. the study was conducted in the hydrogen p...

background: patients with primary sjögren’s syndrome (pss) produce functional igg against cholinoreceptor of exocrine glands modifying their activity. the aim of the present work was to demonstrate pss igg antibodies (pss igg) interacting with m 3 muscarinic acetylcholine receptors (machr) of rats submandibular glands that alter mucin release and production via phospholipase c (plc) and cycloox...

dear editor,   the o 2 -generating enzyme nadph oxidase, plays a crucial role in host defense against microbial infection through the production of reactive oxygen species (ros). 1 the multisubunit nadph oxidase complex can be detected in vitro by the nitroblue tetrazolium test (nbt). 2 the nbt test is used for the diagnosis of chronic granulomatous disease. 3 however, several factors, such as ...