The molecular basis of idiopathic generalized epilepsy remains poorly understood. Absence epilepsy with 3 Hz spike-wave EEG is one of the most common human epilepsies, and is associated with significant morbidity. Several spontaneously occurring genetic mouse models of absence epilepsy are caused by dysfunction of the P/Q-type voltage-gated calcium channel CaV2.1. Such mice exhibit a primary ge...

Inferring information related to users enables to highly improve the quality of many mobile services. For example, knowing the demographic characteristics of a user allows a service to display more accurate information. According to the literature, various works present models to detect them but, to the best of our knowledge, no one is based on the use of the spatio-temporal entropy and introdu...

To assess the impact of the duration of epilepsy, the clusters of seizures and/or epileptic status, the type of epilepsy and seizures, and the mono-/ polytherapy on the quality of life (QOL) of Bulgarian patients with refractory epilepsy (RE). Seventy patients with RE were studied using a purposeful interview on the patients’ disease course, as well as an exam of the patients’ medical documenta...

PURPOSE To analyze the various types of epilepsy in subjects with chromosome 18 aberrations in order to define epilepsy and its main clinical, electroclinical and prognostic aspects in chromosome 18 anomalies. METHODS A careful overview of recent works concerning chromosome 18 aberrations and epilepsy has been carried out considering the major groups of chromosomal 18 aberrations, identified ...

Corresponding Author: Katibeh P. MD Pediatrics department, Shiraz University of Medical Science, Shiraz, Iran Tel: +98 711 6474298 Fax: +98 711 6474298 Email:[email protected] Abstract Objective Approximately 4% of the world’s population experience one or more febrile seizures during their lifetime, and 0.5–1% of the population has active epilepsy. Less than one-third of the reported seizu...

Commentary Idiopathic generalized epilepsies (IGE) represent around 20% of all new-onset epilepsy and are controlled with various an-tiepileptic drugs in up to 80% of the cases. For the remaining 20% with intractable IGE, treatment options are limited. Most new AED clinical trials evaluate cohorts with partial epilepsy. The ketogenic diet has helped many children with catastrophic symptomatic g...

OBJECTIVE To assess efficacy and safety of adjunctive perampanel in patients with drug-resistant, primary generalized tonic-clonic (PGTC) seizures in idiopathic generalized epilepsy (IGE). METHODS In this multicenter, double-blind study (ClinicalTrials.gov identifier: NCT01393743; funded by Eisai Inc.), patients 12 years or older with PGTC seizures and IGE were randomized to placebo or peramp...

A prevalence study of epilepsy in patients with Down syndrome (n = 85) in three age-groups (14-16 years, 23-29 years, 50-60 years) was conducted in the county of Aarhus, Denmark. Seventy-two patients (85%) participated. An interview and a neurological examination were performed. An EEG was recorded in 50 patients. Twelve patients (17%) had epilepsy. ILAE-1981-classification: two with partial se...

drome4), but was still considered to have NCS 'with a generalized EEG pat tern in localization-related epilepsy syndromes' (NCS class IIb}. Pat ient 14 was labelled as belonging to NCS class III (unclassifiable epilepsy syndrome), but the epilepsy syndrome was described as generalized in Table 5 of this paper 2. The integration of patients with severe intellectual deficits into the general epil...

INTRODUCTION One-third of children with epilepsy are classified as having a cryptogenic localization related epilepsy (CLRE). In cohort studies CLRE is often grouped together with either symptomatic localization related epilepsy (SLRE) or idiopathic generalized epilepsy (IGE). Therefore, this categorization is not specific enough and will not lead to prognostic or treatment information. We obje...