introduction: endurance training has significant effects on the renewal of heart tissue, including myosin heavy chain (mhc) proteins. on the other side, purine-rich element-binding protein β (purb) decreases the &alphamhc; gene expression. the aim of this study was to determine the impact of exercise endurance training on purb gene expression in the heart of wistar rats. methods: fourteen rats ...

brucellosis, caused by brucella spp., is an important zoonotic disease that causes abortion and infertility in cattle and undulant fever in humans. various studies have examined cell-free native and recombinant proteins as candidate protective antigens in animal models. among brucella immunogenes, antigen based on ribosomal preparation has been widely investigated. in this study, the immunogeni...

background: angiogenesis, which is required for embryonic development and many physiological events, plays crucial role in many pathological conditions such as tumor growth and metastasis. recent studies indicate anticancer and antitumor properties of saffron against human cancers. many processes are affected by electromagnetic field (emf) and its effect on proliferation and gene expression wer...

objective(s):the limited homing potential of bone-marrow-derived mesenchymal stem cells (bm-msc) is the key obstacle in msc-based therapy. it is believed that chemokines and chemokine receptor interactions play key roles in cellular processes associated with migration. meanwhile, mscs express a low level of distinct chemokine receptors and they even lose these receptors on their surface after a...

objective(s): we aimed to examine association of gene expression of mor1 and glun1 at mrna level in the lumbosacral cord and midbrain with morphine tolerance in male wistar rats. materials and methods: analgesic effects of morphine administrated intraperitoneally at doses of 0.1, 1, 5 and 10 mg/kg were examined using a hot plate test in rats with and without a history of 15 days morphine (10 mg...

vicia sativa l., an annual winter growing leguminous plant, is a valuable source of protein and minerals for cattle. drought is one of the key stress factors that influence plant growth and development. in order to investigate common vetch physiological and molecular responses under normal irrigation (n) and two levels of drought stress [s1= 30% and s2= 10% field capacity (fc)], a greenhouse exp...

Background: Recent studies have found some genetic variants as a risk factor for autoimmune diseases such as Multiple Sclerosis (MS). Cluster of Differentiation 226 (CD226) is one of the risk factors for MS.  Objectives: The present study aimed to evaluate the gene expression of CD226, and its protein serum level in peripheral blood samples of MS patients and healthy individuals. Materials & ...

Objective(s): Nowadays, ionizing radiation (IR) has a significant contribution to the diagnostic and therapeutic medicine, and following that, health risks to individuals through unexpected exposure is greatly increased. Therefore, biological and molecular technology for estimation of dose (biodosimetry) is taken into consideration. In biodosimetry methods stimulation ...

the interaction between immune cells and endothelial lining of blood vessels is vital in many processes such as inflammatory and immune responses as well as cancer cell metastasis. the expression level of vcam-1 is regulated by many factors including the promoter activity that is possibly affected by the single nucleotide polymorphisms (snps) present in the promoter. there are previous reports ...