background: interleukin (il)-23 and il-27 are two il-12-related cytokines which their function may dramatically influence the inflammatory response to tumor development. il-12 and il-27 seem to have antagonistic roles with il-23 in tumor site. in this study, il-23 and il-27 mrna expressions were analyzed in peripheral blood of patients with breast cancer and healthy volunteers using quantitativ...

Human monocyte chemotactic protein-2 (MCP-2) is a member of the CC chemokine family. It is produced by mononuclear leukocytes, diploid fibroblasts, and tumor cells after induction with IL-1b or IFN-g. To understand the transcriptional regulation of the gene, we have analyzed the structure and function of the promoter region. The sequence of the 59-flanking region was determined and the transcri...

IL-1b is produced by many different cell types such as monocytes, tissue macrophages, Background – Accumulating evidence suggests that the cytokine network is central to alveolar macrophages, lymphocytes, mast cells or basophilic cell lines, smooth muscle and the immunopathology of bronchial asthma and the existence of naturally occurring endothelium. It has a wide spectrum of activities but, o...

Background & objective The immunoregulatory effects of transforming growth factor (TGF)-βand interleukin-12 (IL-12) and immunomodulatory actions of vitamin D (VD) were reported in several studies. This study aims to evaluate VD effects on IL-12 and TGF-β expression in experimental autoimmune encephalomyelitis (EAE). Methods:</str...

IL-36 cytokines have recently emerged as mediators of inflammation in autoimmune conditions including psoriasis vulgaris (PsV) and generalized pustular psoriasis (GPP). This study used RNA-seq to profile the transcriptome of primary epidermal keratinocytes (KCs) treated with IL-1B, IL-36A, IL-36B, or IL-36G. We identified some early IL-1B-specific responses (8 h posttreatment), but nearly all l...

BACKGROUND IL-1 is the main regulator of inflammatory reactions. This cytokine also plays an important role in bone tissue remodeling processes. The IL-1α-coding gene and the IL-1β-coding gene are located on the long arm of chromosome 2. These genes contain polymorphic sites. Polymorphic modifications in IL-1-coding genes determine the level of IL-1 release, which can affect bone tissue regener...

Background: Varicocele is a common cause of male infertility with multifactorial etiology. Inflammation is a characteristic pathological event that occurs in the testis tissue following the varicocele. The aim of this study was to investigate expression of nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome components and cytokines in semen of varicocele and control subject...

Objective(s): Allergic rhinitis (AR) is a common hypersensitivity disease worldwide. Immunotherapy has been performed as the best treatment for years. This study aimed to study the gene expression pattern of immune system cells following an accelerated rush immunotherapy protocol (ARIT) in patients with AR.Materials and Methods: Fifteen ...

the aim of this study was to examine the anti-inflammatory effects of co-administration of growthhormone-releasing peptide-2 (ghrp-2) and growth hormone (gh) on tumor necrosis factor-α (tnf-α),interleukin-6 (il-6) and inducible nitric oxide synthase (inos) gene expression induced by lps in the mousebrain. thirty-five male nmri mice (25±5 g) were injected through the mouse tail vein with saline,...