Conventionally nanoparticles (NPs) are synthesized using reducing and capping agents that often hazardous for the environment not economically viable. Consequently, there is a growing requirement of bio-friendly methodologies nanosynthesis via green chemistry approach. The present study discusses frugal cost effective one-pot synthesis AgAu nanohybrid exploiting UV-treatment without use environ...

Evidence has accumulated in recent years of the occurrence, in certain nonlinear systems. of strange nonchaotic attractors. that is attractors whose geometrical character is not simple, but on and near to which the exponential divergence of trajectories. characteristic of chaotic behaviour. does not occur. This behaviour has implications for predictability; small errors in initial conditions gr...

We analyzed the C i lines associated with the damped Lyα system observed at zabs = 1.15 in the spectrum of HE 0515–4414 to derive the C/C ratio. The spectrum was obtained by means of the UV-Visual Echelle Spectrograph (UVES) at the ESO Very Large Telescope (VLT). The obtained lower limit C/C > 80 (2σ C.L.) shows for the first time that the abundance of C in the extragalactic intervening clouds ...

The aim of this study was to develop celecoxib (CLX) -polyvinylpyrrolidone (PVP) solid dispersion nanoparticles with and without surfactant using the supercritical antisolvent (SAS) process. effect different surfactants such as gelucire 44/14, poloxamer 188, 407, Ryoto sugar ester L1695, D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) on nanoparticle formation dissolution well oral abs...

The aim of the present study was to prepare matrix pellets loaded nifedipine (NF) as model drug by pellitization technique by using blend of gelucire 50/13 (GL) and glyceryl palmito stearate (GPS) as hydrophilic and hydrophobic carriers in different concentrations. This system was able to prolong the drug release, minimizing the drug related adverse effects and improve bioavailability in differ...

BACKGROUND The aim of this study was to improve the physicochemical properties and bioavailability of poorly water-soluble sirolimus via preparation of a solid dispersion of nanoparticles using a supercritical antisolvent (SAS) process. METHODS First, excipients for enhancing the stability and solubility of sirolimus were screened. Second, using the SAS process, solid dispersions of sirolimus...

The aim of this study was to prepare and characterize solid dispersions of water insoluble non-steroidal anti-inflammatory drug, indomethacin (IND), with polyethylene glycol 4000 (PEG4000) and Gelucire 50/13 (Gelu.) for enhancing the dissolution rate of the drug. The solid dispersions (SDs) were prepared by hot melting method at 1:1, 1:2 and 1:4 drug to polymer ratios. Scanning electron microsc...

The aim of the study was to evaluate a hot-melt technique for preparation of immediate release spherical microparticles containing clarithromycin with acceptable characteristics and process yield. A modified fluid bed apparatus with rotor insert was used to prepare spherical microparticles in the size range of 125-355 µm. Poloxamer 188, PEG-32 glyceryl laurate (Gelucire 44/14) and a mixture of ...