Monte Carlo tools have been long used to assist the research and development of solutions for proton therapy monitoring. The present work focuses on the prompt-gamma emission yields by comparing experimental data with the outcomes of the current version of Geant4 using all applicable proton inelastic models. For the case in study and using the binary cascade model, it was found that Geant4 over...

monte carlo method is a very accurate method to optimize medical diagnostic radiology spectra and simulation of radiation transportation. using mcnp code, radiology and mammography attenuated x-rayspectraweresimulated.the ipem report number 78 was used as a reference to compare with the geant4 and mcnp simulations because of its popularity and wide availability. the results of geant4 in 40kev s...

We present a multi-scale simulation of the early stage of DNA damages by the indirect action of hydroxyl ((•)OH) free radicals generated by electrons and protons. The computational method comprises of interfacing the Geant4-DNA Monte Carlo with ReaxFF molecular dynamics software. A clustering method was employed to map the coordinates of (•)OH-radicals extracted from the ionization-track-struct...

Brain metastases develop frequently in patients with breast cancer, and present a pressing therapeutic challenge. Expression of vascular cell adhesion molecule 1 (VCAM-1) is upregulated on brain endothelial cells during the early stages of metastasis and provides a target for the detection and treatment of early brain metastases. The aim of this study was to use a model of early brain metastasi...

In this paper, we examine the simulations of two different applications of a Picosecond time-of-flight (TOF) detector. The system uses Cherenkov light created in the window of the photomultiplier tube (PMT) as the detecting medium. We examine the possibilities of using GEANT4 [1], and of using the simulation package called Geant4 Application for Tomographic Emission (GATE) [2]. With some simple...

The modelling with the Geant4 toolkit of moderated 3He-filled proportional neutron counters is studied. The energy deposition spectra by the neutron capture products in the gas counter is compared with experimental results. On the other hand, efficiency calculation for polyethylene moderated proportional counters are compared with experimental and MCNPX results.Finally, the application of the G...

Monte Carlo computer programs such as the GEANT4 toolkit include precise models of particle interactions and can be an invaluable tool for studying the feasibility of new imaging techniques such as proton computed tomography (pCT). Presented in this paper is a comparison of laboratory data with GEANT4 predictions for the imaging characteristics of a simple metal object using a particle beam and...

Applying a Software Process Improvement (SPI) program to GEANT4 [1] represents a rather challenging task, both in terms of software development and organisational matters. The complexity of the software involved, the wide areas of application of the software product, the huge amount of code and Category complexity, and the size and distributed nature of the Collaboration itself are all ingredie...

We report on a comparison study of the Monte Carlo packages GEANT4 and FLUKA for simulating neutron production by muons penetrating deep underground. GEANT4 is found to generate fewer neutrons at muon energies above ∼100 GeV, by at most a factor of 2 in some materials, which we attribute mainly to lower neutron production in hadronic cascades. As a practical case study, the muon-induced neutron...